CUMULATIVE RISKS OF DEVELOPING EXTRAPYRAMIDAL SIGNS, PSYCHOSIS, OR MYOCLONUS IN THE COURSE OF ALZHEIMERS-DISEASE
CUMULATIVE RISKS OF DEVELOPING EXTRAPYRAMIDAL SIGNS, PSYCHOSIS, OR MYOCLONUS IN THE COURSE OF ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1991.00530230049020
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发表时间：
1991-11-01
影响因子：
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通讯作者：
MAYEUX, R
中科院分区：
文献类型：
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作者：
CHEN, JY;STERN, Y;MAYEUX, R
采用Kaplan-Meier生存法对72例可能患有阿尔茨海默病（AD）的患者在AD病程中发生锥体外系体征、精神病和肌阵挛的累积风险进行了评估。 随着AD的进展，不同体征的累积风险函数以不同的速率增加。 累积风险函数的比较显示，在AD的早期阶段，锥体外系体征和精神病比肌阵挛更容易发展。 随着AD的进展，发生肌阵挛的风险与发生其他两种症状的风险一样大。 这项研究表明，锥体外系体征，精神病和肌阵挛代表的发展特征，标志着AD的进展，而不是疾病亚型的指标。 估计的累积风险函数为临床体征出现的时间和可能性设定了合理的预期。 反过来，这可能有助于疾病预后，因为这些体征的生物学基础已经建立，并且它们已被证明可以预测疾病过程的其他标志物。
Cumulative risks of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease (AD) were estimated in 72 patients with probable AD by the Kaplan-Meier survival method. The cumulative risk functions were found to increase at different rates for different signs as AD progressed. Comparisons of the cumulative risk functions revealed that in the early stages of AD, extrapyramidal signs and psychosis were more likely to develop than myoclonus. As AD progressed, the risk of developing myoclonus became as great as that of developing the other two signs. This study suggests that extrapyramidal signs, psychosis, and myoclonus represent developmental features that mark the progression of AD, rather than indicators of disease subtypes. The estimated cumulative risk functions set a reasonable expectation for the timing and likelihood of the emergence of the clinical signs. This, in turn, might aid in disease prognosis because the biological bases of these signs have been established and they have been shown to be predictive of other markers of disease course.