Increased Resting State Functional Connectivity in the Default Mode Network in Recovered Anorexia Nervosa
Increased Resting State Functional Connectivity in the Default Mode Network in Recovered Anorexia Nervosa
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DOI：
10.1002/hbm.22202
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发表时间：
2014-02-01
影响因子：
4.8
通讯作者：
McCabe, Ciara
中科院分区：
文献类型：
--
作者：
Cowdrey, Felicity A.;Filippini, Nicola;McCabe, Ciara
脑功能成像研究表明，在认知和情绪任务范式中，从神经性厌食症(AN)中恢复的个体都有异常的神经活动。有人认为，这种持续到康复的异常活动可能支持了这种疾病的神经生物学，并构成了AN的神经生物标志物。然而，到目前为止，还没有研究评估在没有任务诱导活动的情况下，从AN恢复的神经网络的功能变化。因此，这项研究的目的是调查从神经性厌食症中恢复的非药物治疗女性的全脑静息状态的功能连接。16名未服药的神经性厌食症恢复者和15名健康对照受试者进行了功能磁共振成像扫描。独立成分分析揭示了功能相关的静息状态网络。双重回归分析显示，默认模式网络(DMN)的时间相关性(连贯性)增加，这被认为与自我参照加工有关。具体地说，与健康对照组参与者相比，恢复的神经性厌食症参与者显示出DMN与楔前叶和背外侧前额叶皮质/额下回之间的时间一致性增加。这些发现支持这样一种观点，即参与自我参照加工和认知控制的区域的静息状态功能连接功能障碍可能是神经性厌食症发展的易损性标志。Hum Brain Mapp 35：483-491,2014。(C)2012年威利期刊公司。
Functional brain imaging studies have shown abnormal neural activity in individuals recovered from anorexia nervosa (AN) during both cognitive and emotional task paradigms. It has been suggested that this abnormal activity which persists into recovery might underpin the neurobiology of the disorder and constitute a neural biomarker for AN. However, no study to date has assessed functional changes in neural networks in the absence of task-induced activity in those recovered from AN. Therefore, the aim of this study was to investigate whole brain resting state functional connectivity in nonmedicated women recovered from anorexia nervosa. Functional magnetic resonance imaging scans were obtained from 16 nonmedicated participants recovered from anorexia nervosa and 15 healthy control participants. Independent component analysis revealed functionally relevant resting state networks. Dual regression analysis revealed increased temporal correlation (coherence) in the default mode network (DMN) which is thought to be involved in self-referential processing. Specifically, compared to healthy control participants the recovered anorexia nervosa participants showed increased temporal coherence between the DMN and the precuneus and the dorsolateral prefrontal cortex/inferior frontal gyrus. The findings support the view that dysfunction in resting state functional connectivity in regions involved in self-referential processing and cognitive control might be a vulnerability marker for the development of anorexia nervosa. Hum Brain Mapp 35:483-491, 2014. (c) 2012 Wiley Periodicals, Inc.