Spotlight on metabolic remodelling in heart failure.
Spotlight on metabolic remodelling in heart failure.
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DOI：
10.1093/cvr/cvr077
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发表时间：
2011-05
影响因子：
10.8
通讯作者：
T. Doenst;E. Abel
中科院分区：
文献类型：
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作者：
T. Doenst;E. Abel
这篇社论引用了9篇评论文章的集合，这些文章是为这期关于心力衰竭代谢重塑的特刊所邀请的，由Torsten Doenst和E。Dale Abel术语“重塑”在心力衰竭的背景下被大量使用，具有许多不同的含义。1 -3最初在大鼠模型中将其描述为远端心肌对左前降支冠状动脉闭塞引起的局部梗死的结构和功能反应。4此后，大量的实验和临床研究已经解决了重塑的机制，并且该概念与心力衰竭的发展广泛相关。5然而，直到最近，重塑的代谢方面还没有得到很好的研究。新分子技术的发展，包括基因表达全球分析的各种方法6、7和基础广泛的方法，如蛋白质组学和代谢组学8 -10，提供了大量关于潜在机制的新信息。然而，从这些技术中获得的信息代表了功能连续体的“快照”，因为它们需要通常来自特定时间点的组织样本。虽然这些方法已被证明是非常有价值的，但许多发现的功能相关性并不总是明显的。例如，经典代谢方法的使用已经复苏，例如评估底物利用率，酶活性和ATP合成率。在心力衰竭领域，这些发展特别重要，因为收缩功能的变化与能量需求的变化（即能量产生和转换过程）相关。在这个聚光灯问题，一系列的评论文章提出了解决目前的知识，在心肌的能量产生过程的变化的条件下，直接或间接导致...
This editorial refers to a collection of nine review articles invited for this special issue on metabolic remodelling in heart failure, guest edited by Torsten Doenst and E. Dale Abel The term ‘remodelling’ has been abundantly used in the context of heart failure with many different meanings.1–3 It was originally described in a rat model as the structural and functional response of the remote heart muscle to a local infarct caused by the occlusion of the left anterior descending coronary artery.4 Thereafter, a plethora of experimental and clinical studies have addressed mechanisms of remodelling and the concept is widely linked to the development of heart failure.5 However, metabolic aspects of remodelling have until recently been less well investigated. The development of new molecular techniques, including diverse approaches to global analysis of gene expression6,7 and broad-based approaches such as proteomics and metabolomics8–10 has provided a wealth of new information on underlying mechanisms. However, the information derived from these techniques represent a ‘snapshot’ of a functional continuum because they require tissue samples which are usually derived from a specific time point. Although these approaches have proved to be extemely valuable, the functional relevance of many findings is not always obvious. For example, there has been a resurgence in the use of classic metabolic approaches such as assessing rates of substrate utilization, enzyme activities, and ATP synthesis rates. In the heart failure field, these developments are specifically important since changes in contractile function are associated with changes in energy demand (i.e. the processes involved in energy production and conversion). In this spotlight issue, a series of review articles are presented to address the current knowledge of changes in the energy-producing processes of the myocardium under conditions that directly or indirectly lead to …