Simian foamy virus infections in a baboon breeding colony
Simian foamy virus infections in a baboon breeding colony
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DOI：
10.1006/viro.2000.0649
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发表时间：
2000-12-05
期刊：
影响因子：
3.7
通讯作者：
Eberle, R
中科院分区：
文献类型：
--
作者：
Blewett, EL;Black, DH;Eberle, R
研究了猴泡沫病毒（SFVs）在狒狒中的流行、传播和变异。繁殖群中超过95%的成年狒狒以及最近进口的成年动物具有高升的抗SFV血清IgG。在6个月龄的婴儿血清中可检测到母体抗体。大约30%的婴儿在1岁时经历了SFV感染。SFV在口腔分泌物中的脱落是常见的，13%的样本来自正常成年动物，35%来自含有感染性SFV的免疫抑制动物。SFV分离自三个狒狒亚种（橄榄狒狒、黄色狒狒和查克玛狒狒），并通过PCR扩增前病毒的pol和LTR区域的序列并测序。系统发育分析表明，所有狒狒分离株形成了一个单一的谱系不同的SFV的其他非洲猴物种。在狒狒SFV谱系内，明显存在两个不同的分支，由来自黄色和橄榄色狒狒的分离株和来自chacma狒狒的分离株组成。竞争ELISA表明，虽然这两组SFV分离物非常密切相关，但它们之间确实存在抗原差异。从一个钻和一个山海关SFV分离株是不同的狒狒SFV分离株，遗传和抗原性。(C)北京大学出版社.
The prevalence, transmission, and Variation of simian foamy viruses (SFVs) in baboons was investigated. Over 95% of adult baboons in the breeding colony as well as recently imported adult animals had high liters of anti-SFV serum IgG. Maternal antibody was detectable in infants' serum up to 6 months of age. Approximately 30% of infants in breeding harems experienced SFV infections by 1 year of age. Shedding of SFV in oral secretions was common, with 13% of samples from normal adult animals and 35% from immunosuppressed animals containing infectious SFV. SFV was isolated from three baboon subspecies (olive, yellow, and chacma baboons) and sequences from both the pol and the LTR regions of the provirus were amplified by PCR and sequenced. Phylogenetic analysis indicated that all baboon isolates formed a single lineage distinct from SFVs of other African monkey species. Within the baboon SFV lineage, two distinct clades were apparent, which consisted of isolates from yellow and olive baboons and isolates from chacma baboons. Competition ELISAs indicated that, while SFV isolates of these two groups were very closely related, antigenic differences do exist between them. SFV isolates from a drill and a mandrill were distinct from baboon SFV isolates, both genetically and antigenically. (C) 2000 Academic Press.