Endothelial Regeneration

Endothelial Regeneration
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内皮再生

DOI:
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发表时间:
2007
期刊:
影响因子:
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通讯作者:
M. Reidy
M. Reidy
中科院分区:
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文献类型:
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作者:
T. Tada;M. Reidy

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用细尼龙丝去除大鼠胸主动脉的内皮细胞,去除一排宽度约为 100 pI 的内皮细胞,并使血小板粘附在暴露的内皮下层上。对另一组大鼠进行假手术,仅损伤腹主动脉,另一组大鼠用作对照。每只动物连续用 3H-胸苷(6.7 Ci/mM,10 uCi/hr)标记7天,然后处死它们,并用醛灌注固定主动脉。对每个主动脉的切片进行放射自显影处理。受到尼龙丝损伤的动物的胸主动脉未显示内膜增厚,但胸腺明显增加。
Rat thoracic aortas were denuded of endothelial cells with a fine nylon filament, which removed a row of endothelium approximately 100 pI in width and caused platelets to adhere to the exposed subendothelium. A further group ofrats was subjected to a sham operation where only the abdominal aorta was injured, and another group of rats was used as controls. Each animal was continuously labeled with 3H-thymidine (6.7 Ci/mM, 10 uCi/hr) for 7 days, at which time they were killed and the aortas perfusion-fixed with aldehydes. Sections ofeach aorta were processed for autoradiography. The thoracic aortas from animals subjected to the nylon filament injury showed no intimal thickening, but there was a significant increase in the thymi-
DOI: --
发表时间: 1982
期刊: The Journal of biological chemistry
影响因子: --
作者:
CastellotJr,JJ;Favreau,LV;Karnovsky,MJ;Rosenberg,RD
通讯作者: Rosenberg,RD
DOI: --
发表时间: 1983
期刊: Laboratory investigation; a journal of technical methods and pathology
影响因子: --
作者:
Reidy,MA;Clowes,AW;Schwartz,SM
通讯作者: Schwartz,SM