Clinical analysis of small-sized peripheral lung cancer
Clinical analysis of small-sized peripheral lung cancer
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DOI：
10.1016/s0022-5223(98)70399-x
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发表时间：
1998-05-01
影响因子：
6
通讯作者：
Yokoyama, A
中科院分区：
文献类型：
--
作者：
Koike, T;Terashima, M;Yokoyama, A
目的：在日本，随着肺癌筛查计划的启动，直径为2cm或更小的小尺寸周围型肺癌一直在增加。本研究的目的是确定小肺癌的临床病理行为。研究方法：收集1980 ~ 1996年间手术切除的cT 1 NO、周围型非小细胞肺癌患者1996例，按肿瘤直径或组织学类型分组，分析其临床病理特征。根据X线测量的直径，将患者分为两组：病变直径小于或等于2cm的c-S组和病变直径为2.1 ~ 3cm的c-L组。结果：c-S组淋巴结转移率为18%，c-L组为23%，临床组为21%。c-S组和c-L组的进展率分别为19%和26%，5年生存率分别为79.5%和69.3%。两组之间存在显著差异）。结论：与病灶直径2.1 ~ 3cm的患者相比，小体积肺癌患者的进展状态较轻，预后较好。
Objective: In Japan, with the initiation of the lung cancer screening program, small-sized peripheral lung cancer in which the diameter is 2 cm or less has been increasing. The purpose of this study is to determine the clinicopathologic behavior of small-sized lung cancer. Methods: Pour hundred ninety-six patients with cT1 NO, peripheral, resected non-small-cell lung cancer, who were operated on between 1980 and 1996, were selected, grouped by tumor diameter or histologic type, and then analyzed for clinicopathologic behavior. On the basis of measured diameter roentgenographically, the patients were divided into two groups; group c-S with lesions 2 cm or less in diameter and group c-L with lesions 2.1 to 3 cm in diameter. Results: Lymph node metastasis was recognized in 18% of group c-S, in 23% of group c-L, and in 21% for the entire clinical group. The rate of those with the progressive state was 19% in group c-S and 26% in group c-L, The 5-year survival was 79.5% in group c-S and 69.3% in group c-L (i.e., there was a significant difference between the two groups). Conclusion: Compared with the patients with lesions 2.1 to 3 cm in diameter, the patients with small-sized lung cancer had a milder progressive state and a better prognosis.