A Novel Neuronal Pathway for Visually Guided Escape in Drosophila melanogaster
A Novel Neuronal Pathway for Visually Guided Escape in Drosophila melanogaster
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DOI：
10.1152/jn.00073.2009
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发表时间：
2009-08-01
影响因子：
2.5
通讯作者：
Gabbiani, Fabrizio
中科院分区：
文献类型：
--
作者：
Fotowat, Haleh;Fayyazuddin, Amir;Gabbiani, Fabrizio
张建军，张建军，张建军，等。一种新的视觉引导下黑胃果蝇逃跑的神经通路。中国生物医学工程学报[J] . 32(2): 875-885, 2009。2009年5月27日首次发表；doi: 10.1152 / jn.00073.2009。黑腹果蝇对碰撞过程中接近的物体表现出强烈的逃逸反应。尽管一对被称为巨纤维（GFs）的大型指令中间神经元被认为触发了这些行为，但它们的作用尚未得到直接证明。在这里，我们发现逃避视觉刺激（如接近捕食者产生的视觉刺激）并不依赖于GFs的激活，而是由一个比GFs更复杂、更少刻板的运动序列组成。相反，逃跑的时间与先前未描述的下降中间神经元的活动密切相关，这些神经元发出信号表明接近物体的阈值角大小。这些中间神经元的活动模式与一些物种（包括鸽子、青蛙和蝗虫）的视觉逃避回路具有相同的特征，因此可能是在类似的约束下进化的。这些结果表明，果蝇的视觉诱发逃逸可以依赖于至少两个下行神经元通路：GFs和我们在电生理学上描述的新通路。这些通路表现出非常不同的感觉活动模式，并与两种不同的运动程序相关。
Fotowat H, Fayyazuddin A, Bellen HJ, Gabbiani F. A novel neuronal pathway for visually guided escape in Drosophila melanogaster. J Neurophysiol 102: 875-885, 2009. First published May 27, 2009; doi:10.1152/jn.00073.2009. Drosophila melanogaster exhibits a robust escape response to objects approaching on a collision course. Although a pair of large command interneurons called the giant fibers (GFs) have been postulated to trigger such behaviors, their role has not been directly demonstrated. Here, we show that escape from visual stimuli like those generated by approaching predators does not rely on the activation of the GFs and consists of a more complex and less stereotyped motor sequence than that evoked by the GFs. Instead, the timing of escape is tightly correlated with the activity of previously undescribed descending interneurons that signal a threshold angular size of the approaching object. The activity pattern of these interneurons shares features with those of visual escape circuits of several species, including pigeons, frogs, and locusts, and may therefore have evolved under similar constraints. These results show that visually evoked escapes in Drosophila can rely on at least two descending neuronal pathways: the GFs and the novel pathway we characterize electrophysiologically. These pathways exhibit very different patterns of sensory activity and are associated with two distinct motor programs.