WEE1 tyrosine kinase, a novel epigenetic modifier.
WEE1 tyrosine kinase, a novel epigenetic modifier.
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DOI：
10.1016/j.tig.2013.02.003
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发表时间：
2013-07
影响因子：
11.4
通讯作者：
Mahajan, Nupam P.
中科院分区：
文献类型：
--
作者：
Mahajan, Kiran;Mahajan, Nupam P.
The cell cycle requires cells to duplicate their chromatin, DNA, and histones, while retaining a subset of epigenetic marks, in a highly coordinated manner. The WEE1 kinase was identified as an important regulator during S phase, preventing entry into mitosis until DNA replication has been completed. Interestingly, WEE1 has also emerged as a key player in regulating histone synthesis. It phosphorylates histone H2B at tyrosine 37 in the nucleosomes found upstream of the histone gene cluster, which suppresses histone transcription in late S phase. These observations highlight a dual role for WEE1 as both a mitotic gatekeeper and a surveyor of chromatin synthesis, providing a direct link between epigenetics and cell cycle progression. Importantly, this link has implications for the design of novel epigenetic inhibitors targeting cancers that display elevated expression of this kinase.
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