Total-body potassium in hypertension patients during prolonged diuretic therapy.
Total-body potassium in hypertension patients during prolonged diuretic therapy.
复制标题
长期利尿治疗期间高血压患者的全身钾含量。
DOI：
10.1016/s0140-6736(72)91275-5
复制
发表时间：
1972
期刊：
影响因子：
168.9
通讯作者：
B. Jasani
中科院分区：
文献类型：
--
作者：
C. Edmonds;B. Jasani
使用高灵敏度全身计数器测量钾 40 含量，在长达 3 年的时间间隔内对 20 名接受连续利尿治疗的高血压患者进行了血浆钾浓度和全身钾浓度的测定。在一些患者中观察到血浆和全身钾显着降低，但没有产生明确的症状或体征。 5 名患者无需补充钾即可将血浆钾浓度和全身钾维持在满意的水平，12 名患者需要 24 meq。每天补充，而其中三个需要比此或螺内酯更多的钾才能获得满意的维持。四名心脏受累患者的体内钾含量相对较低，血浆浓度正常。平均下降 1 毫克当量。每升血浆钾浓度与全身钾减少约 20% 相关，但存在相当大的差异。当血浆钾浓度为3·5meq时。每升或更多，体内钾含量通常减少不超过 10%。一旦建立了合适的治疗方案，钾状态就相对稳定，因此每隔四到六个月进行一次检查似乎就足够了。
Plasma-potassium concentration and total-body potassium, measured using a high sensitivity whole-body counter to estimate potassium-40 content, have been determined at intervals over a period of up to 3 years in twenty hypertensive patients on continuous diuretic therapy. Considerable reductions of plasma and total-body potassium were observed in some patients without production of definite symptoms or signs. Five patients required no potassium supplement to maintain plasma-potassium concentration and total-body potassium at satisfactory levels, twelve needed 24 meq. per day supplement, while three required more potassium than this or spironolactone for satisfactory maintenance. Four patients with cardiac involvement had a relatively low body-potassium with a normal plasma-concentration. On average a fall of 1 meq. per litre in plasma-potassium concentration was associated with a reduction of about 20% in the total-body potassium, but there was considerable variation. When the plasma-potassium concentration was 3·5 meq. per litre or more, the total-body potassium was not usually reduced by more than 10%. Once a suitable regimen was established, the potassium state was relatively stable, so that checks at intervals of four to six months appeared adequate.