Long-term hydrolytic degradation study on polymer-based embroidered scaffolds for ligament tissue engineering
Long-term hydrolytic degradation study on polymer-based embroidered scaffolds for ligament tissue engineering
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DOI：
10.1177/1528083716686940
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发表时间：
2018-02-01
影响因子：
3.2
通讯作者：
Heinrich, Gert
中科院分区：
文献类型：
--
作者：
Hahn, Judith;Breier, Annette;Heinrich, Gert
前交叉韧带损伤后，需要进行机械稳定的组织置换以保持膝关节稳定性并避免后续损伤。前交叉韧带的组织工程需要具有可控降解特性的生物相容性支架，以提供3至6个月的机械支撑。有人认为，由聚乳酸和聚（乳酸-共-己内酯）纤维制成的刺绣纺织品支架是一种有前途的方法，用于韧带组织工程与适应的功能化和细胞接种策略。因此，在生理条件下研究了由聚乳酸和聚乳酸与聚（乳酸-共-己内酯）纤维的组合制成的刺绣支架的水解降解行为168天。分析了改性前后的力学性能、分子量和表面结构的变化。在水解6个月后，可以证明由聚乳酸纤维制成的支架具有与天然前交叉韧带组织相当的足够的机械性能。这些结果阐明了使用刺绣支架韧带组织工程的潜力。
Following anterior cruciate ligament injury, a mechanically stable tissue replacement is required for knee stability and to avoid subsequent damages. Tissue engineering of the anterior cruciate ligament demands a biocompatible scaffold with a controllable degradation profile to provide mechanical support for 3 to 6 months. It has been argued that embroidered textile scaffolds made of polylactic acid and poly(lactic-co--caprolactone) fibres are a promising approach for the ligament tissue engineering with an adapted functionalization and cell seeding strategy. Therefore, the hydrolytic degradation behaviour of embroidered scaffolds made of polylactic acid and a combination of polylactic acid and poly(lactic-co--caprolactone) fibres was investigated under physiological conditions for 168 days. The changes in the mechanical behaviour, the molecular weights as well as the surface structures were analysed. Sufficient mechanical properties comparable to native anterior cruciate ligament tissue could be demonstrated for scaffolds made of polylactic acid fibres after 6 months under hydrolysis. These results clarify the potential of using embroidered scaffolds for ligament tissue engineering.