Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer
Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer
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DOI：
10.1016/j.biomaterials.2005.07.013
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发表时间：
2006-02-01
期刊：
影响因子：
14
通讯作者：
Yaszemski, MJ
中科院分区：
文献类型：
--
作者：
Wang, SF;Lu, LC;Yaszemski, MJ
通过一种新的合成方法，开发了一系列可自交联且可生物降解的聚富马酸己内酯(PCLF)、聚富马酸乙二醇酯(PEGF)及其共聚物PEGF-co-PCLF，用于组织工程应用。目前的方法使用碳酸钾(K2CO3)作为质子清除剂，而不是以前报道的三乙胺。新的合成路线更方便、更省时，而且合成的聚合物颜色更浅，更适合于通过光引发进行自交联。这组聚合物基本上是富马酸氯的共聚物，富马酸氯含有用于原位交联的双键，与聚己内酯(PCL)或/和具有促进自交联的柔性链的聚乙二醇(PEG)共聚。PCLF和PEGF及其两亲性共聚物PEGF-co-PCLF可以在不使用交联剂的情况下进行自交联或光交联制得支架。我们的结果表明，这些聚合物作为可注射、可自交联和可光交联的材料在不同的组织工程应用中具有潜在的应用价值。(C)2005爱思唯尔有限公司。保留所有权利。
A series of self-crosslinkable and biodegradable polymers, poly(caprolactone fumarate) (PCLF), poly(ethylene glycol fumarate) (PEGF), and their copolymer PEGF-co-PCLF, has been developed for tissue engineering applications using a novel synthesis method. The current method employs potassium carbonate (K2CO3) other than the previously reported triethylamine, as the proton scavenger. The new synthetic route is more convenient and less time-consuming to carry out, and the synthesized polymers have a much lighter color, which renders them more suitable for self-crosslinking via photo-initiation. This group of polymers are essentially copolymers of fumaryl chloride, which contains double bonds for in situ crosslinking, with poly(epsilon-caprolactone) (PCL) or/and poly(ethylene glycol) (PEG) that has a flexible chain to facilitate self-crosslinking. Both PCLF and PEGF, and their amphiphilic copolymer PEGF-co-PCLF could be self-crosslinked or photocrosslinked to produce scaffolds without the use of a crosslinking agent. Our results suggest that these polymers are potentially useful as injectable, self-crosslinkable, and photo-crosslinkable materials for diverse tissue engineering applications. (c) 2005 Elsevier Ltd. All rights reserved.