Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.
Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.
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DOI：
10.1083/jcb.200403174
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发表时间：
2004-06-21
期刊：
影响因子：
--
通讯作者：
McCarthy JB
中科院分区：
文献类型：
--
作者：
Yang J;Price MA;Neudauer CL;Wilson C;Ferrone S;Xia H;Iida J;Simpson MA;McCarthy JB
Melanoma chondroitin sulfate proteoglycan (MCSP) is an early cell surface melanoma progression marker implicated in stimulating tumor cell proliferation, migration, and invasion. Focal adhesion kinase (FAK) plays a pivotal role in integrating growth factor and adhesion-related signaling pathways, facilitating cell spreading and migration. Extracellular signal–regulated kinase (ERK) 1 and 2, implicated in tumor growth and survival, has also been linked to clinical melanoma progression. We have cloned the MCSP core protein and expressed it in the MCSP-negative melanoma cell line WM1552C. Expression of MCSP enhances integrin-mediated cell spreading, FAK phosphorylation, and activation of ERK1/2. MCSP transfectants exhibit extensive MCSP-rich microspikes on adherent cells, where it also colocalizes with α4 integrin. Enhanced activation of FAK and ERK1/2 by MCSP appears to involve independent mechanisms because inhibition of FAK activation had no effect on ERK1/2 phosphorylation. These results indicate that MCSP may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth.
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影响因子：
4.8
作者：
Iida, J;Pei, D;McCarthy, JB
通讯作者：
McCarthy, JB
影响因子：
4.8
作者：
Goretzki, L;Burg, MA;Stallcup, WB
通讯作者：
Stallcup, WB
影响因子：
3.1
作者：
Hecker, TP;Gladson, CL
通讯作者：
Gladson, CL
DOI：
10.1083/jcb.103.5.1699
发表时间：
1986-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Garrigues HJ;Lark MW;Lara S;Hellström I;Hellström KE;Wight TN
通讯作者：
Wight TN
DOI：
10.1083/jcb.118.2.431
发表时间：
1992-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Iida J;Skubitz AP;Furcht LT;Wayner EA;McCarthy JB
通讯作者：
McCarthy JB