Vasopressin constricts outer medullary descending vasa recta isolated from rat kidneys.
Vasopressin constricts outer medullary descending vasa recta isolated from rat kidneys.
复制标题
加压素收缩从大鼠肾脏分离的外髓降血管直肠。
DOI：
10.1152/ajprenal.1997.272.1.f147
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Pallone,TL
中科院分区：
文献类型：
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作者：
Turner,MR;Pallone,TL
精氨酸加压素（AVP）可选择性地减少肾髓质的血流量，但收缩血管的部位尚不明确。我们已经研究了加压素受体激动剂和拮抗剂的直径上的外髓降直血管（OMDVR），分离和灌注在体外的影响。AVP对OMDVR有收缩作用，其作用机制可能与V1 a受体有关。腔外AVP（10（-10）-10（-6）M）或选择性V1 a受体激动剂[Phe 2，Ile 3，Orn 8]-加压素（PO-VT，10（-8）M）使OMDVR局灶性和短暂性收缩（在较高AVP浓度下）。V1 b激动剂[deamino-Cys 1，D-Arg 8]加压素（DP-VP; 10（-8）M）和V2激动剂[deamino-Cys 1，D-Arg 8]加压素（DDAVP; 10（-8）M）不收缩OMDVR。V1 a拮抗剂[d（CH 2）5（1），O-Me-Tyr 2，Arg 8]vasopressin（CTM-VP，10（-10）10（-8）M）抑制AVP 10（-9 M）引起的血管收缩，而V2拮抗剂[d（CH 2）5（1），D-Ile 2，Ile 4 Arg 8]vasopressin（II-VP）在低浓度（10（-10）M）时则不抑制。刺激V2似乎抑制V1 a收缩OMDVR。DDAVP阻断PO-VT（10（-8）M）收缩，OMDVR扩张后与PO-VT预收缩。
Arginine vasopressin (AVP) can selectively decrease blood flow in the renal medulla, but the sites of vasoconstriction are uncertain. We have examined the effects of vasopressin-receptor agonists and antagonists on the diameters of outer medullary descending vasa recta (OMDVR), isolated and perfused in vitro. AVP can constrict OMDVR, apparently via V1a-receptors. Ablumenal AVP (10(-10)-10(-6)M) or the selective V1a-receptor agonist [Phe2, Ile3, Orn8]-vasopressin (PO-VT, 10(-8) M) constricted OMDVR focally and (at higher AVP concentrations) transiently. The V1b agonist ideamino-Cys1,D-3-(pyridyl)Ala2,Arg8)vasopressin (DP-VP; 10(-8) M) and the V2 agonist [deamino-Cys1, D-Arg8]vasopressin (DDAVP; 10(-8) M) did not constrict OMDVR. The V1a antagonist [d(CH2)5(1), O-Me-Tyr2,Arg8]vasopressin (CTM-VP, 10(-10) 10(-8) M) inhibited vasoconstriction by AVP 10(-9 M), whereas the V2 antagonist [d(CH2)5(1), D-Ile2,Ile4 Arg8]vasopressin (II-VP) at low concentration (10(-10) M) did not. V2 stimulation seems to inhibit V1a constriction of OMDVR. DDAVP prevented constriction by PO-VT (10(-8) M) applied at the same time and dilated OMDVR preconstricted with PO-VT.