The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions
The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions
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DOI：
10.1042/bst0270142
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发表时间：
1999-02-01
影响因子：
3.9
通讯作者：
Aguiar, DJ
中科院分区：
文献类型：
--
作者：
Knudson, CB;Nofal, GA;Aguiar, DJ
透明质酸[L]是软骨细胞外基质的关键成分，是软骨蛋白多糖聚合体的中心细丝。这种富含糖胺多糖的基质成分是在特定的胶原蛋白网络中组织的[Z]。软骨细胞与基质(细胞周基质)之间的界面区可作为软骨细胞定向基质的成核模板。本报告的重点是透明质酸在基质组装中的重要作用及其与软骨细胞上的细胞表面受体的相互作用，目的是发展软骨细胞细胞外基质作为透明质酸介导的细胞-基质相互作用的模型的想法。
Hyaluronan [l] is a key component of the extracellular matrix of cartilage, functioning as the central filament of the cartilage proteoglycan aggregate. This glycosaminoglycan-rich component of the matrix is organized within a specific collagen network [Z]. The interface zone between the chondrocytes and the matrix, the pericellular matrix, may function as a nucleating template for chondrocyte-directed matrix assem-bly. The focus of this report is the essential role of hyaluronan in matrix assembly and its interaction with its cell surface receptors on the chondrocytes, with the goal of developing the idea of the chondrocyte pericellular matrix as a model for hyaluronan-mediated cell-matrix interactions.