Breast Cancer Subtypes in Asian-Americans Differ According to Asian Ethnic Group
Breast Cancer Subtypes in Asian-Americans Differ According to Asian Ethnic Group
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DOI：
10.1007/s10903-012-9577-7
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发表时间：
2012-10-01
影响因子：
1.9
通讯作者：
Klein, Paula
中科院分区：
文献类型：
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作者：
Chuang, Ellen;Christos, Paul;Klein, Paula
乳腺癌预后和乳腺癌分子亚型因人种/种族而异。我们确定了乳腺癌亚型的分布是否在不同的亚洲种族群体中存在差异。使用免疫组化替代物的四个分子定义的乳腺癌亚型，我们的特点乳腺癌亚型的346名亚洲受试者在两个纽约市机构治疗。我们发现，中国人和日本人预后良好的管腔A型癌的比例（分别为66.7%和80.0%）高于菲律宾人和韩国人（48.5%和47.1%）（P = 0.001）。与其他族裔群体（23.6%）相比，菲律宾人HER-2/neu阳性癌症的比例更高（45.6%）（P = 0.002）。韩国人的三阴性癌症比例（23.5%）高于其他种族（7.5%）（P = 0.06）。结果表明，不同的亚洲种族群体之间存在乳腺癌肿瘤生物学差异，并对癌症护理和研究产生影响。未来对亚裔美国人乳腺癌的研究应该区分不同的种族群体。
Breast cancer prognosis and breast cancer molecular subtype vary by race/ethnicity. We determined whether the distribution of breast cancer subtypes varies among different Asian ethnic groups. Using immunohistochemical surrogates for the four molecularly defined breast cancer subtypes, we characterized breast cancer subtype for 346 Asian subjects treated at two New York City institutions. We found that Chinese and Japanese had a higher proportion of good-prognosis luminal A cancers (66.7 and 80.0%, respectively) compared to Filipinos and Koreans (48.5 and 47.1%) (P = 0.001). Filipinos had a higher proportion of HER-2/neu positive cancers (45.6%) compared to other ethnic groups (23.6%) (P = 0.002). Koreans had a higher proportion of triple negative cancers (23.5%) compared to other ethnic groups (7.5%) (P = 0.06). The results suggest that differences exist in breast cancer tumor biology among distinct Asian ethnic groups and have implications for cancer care and research. Future studies of breast cancer in Asian-Americans should distinguish among the different ethnic groups.