Endocrine disrupters and human puberty
Endocrine disrupters and human puberty
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DOI：
10.1111/j.1365-2605.2005.00561.x
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发表时间：
2006-02-01
影响因子：
--
通讯作者：
Schoeters, G
中科院分区：
文献类型：
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作者：
Den Hond, E;Schoeters, G
在这篇文献综述中，总结了研究内分泌干扰物对青春期开始影响的流行病学研究。据报道，女孩在接触多氯联苯 (PCB)、多溴联苯 (PBB)、持久性杀虫剂 [二氯二苯基三氯乙烷 (DDT)] 和邻苯二甲酸酯后，初潮年龄会提前。然而，其他几项研究发现这些化合物对初潮或青春期坦纳阶段的年龄没有影响。一项研究报告了二恶英类化合物对乳房发育的延迟作用。在男孩中，接触多氯联苯、多氯二苯并呋喃或杀虫剂硫丹与青春期延迟或阴茎长度缩短有关。群体研究中发现的大部分结果都与动物实验研究一致。然而，具有拮抗作用（雌激素、抗雌激素、抗雄激素）的不同成分的混合物以及对最关键暴露窗口（产前、围产期和青春期）的了解有限可能会妨碍结果的解释。
In this overview of the literature, epidemiological research studying the effect of endocrine disrupters on the onset of puberty is summarized. In girls, earlier age at menarche was reported after exposure to polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), persistent pesticides [dichlorodiphenyltrichloroethane (DDT)] and phthalate esters. However, several other studies found no effect of these compounds on age at menarche or pubertal Tanner stages. One study reported a delaying effect of dioxin-like compounds on breast development. In boys, exposure to PCBs, PCDFs or the pesticide endosulfan was associated with delayed puberty or decreased penile length. Much of the results found in population studies are in accordance with experimental studies in animals. However, the mixture of different components with antagonistic effects (oestrogenic, anti-oestrogenic, anti-androgenic) and the limited knowledge about the most critical window for exposure (prenatal, peri-natal and pubertal) may hamper the interpretation of results.