A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.
A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.
复制标题
急性呼吸窘迫综合征生物标志物的病理生理方法。
DOI：
10.1155/2016/3501373
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Jabaudon M
中科院分区：
文献类型：
--
作者：
Blondonnet R;Constantin JM;Sapin V;Jabaudon M
急性呼吸窘迫综合征（ARDS）是一种急性发作的缺氧性疾病，伴有放射学检查双侧肺部浸润。其特征是急性渗出期伴有弥漫性肺泡损伤和肺水肿，随后是纤维增殖期。尽管对 ARDS 病理学的了解有所提高，但我们预测 ARDS 发展和对该疾病患者进行风险分层的能力仍然有限。生物标志物可能有助于识别发生 ARDS 风险最高的患者、评估治疗反应、预测结果并优化临床试验的入组。在对 ARDS 病理学进行简短描述后，我们在此回顾了支持各种 ARDS 生物标志物在 ARDS 相关肺损伤和/或修复中的主要生物学作用的价值的科学证据。正在进行的研究旨在识别和表征新型生物标志物，以突出肺损伤和修复的相关机制探索，并最终为 ARDS 患者开发创新的治疗方法。本综述将重点关注 ARDS 生物标志物的病理生理学、诊断和治疗意义及其最终改善患者护理的效用。
Acute respiratory distress syndrome (ARDS) is an acute-onset hypoxic condition with radiographic bilateral lung infiltration. It is characterized by an acute exudative phase combining diffuse alveolar damage and lung edema followed by a later fibroproliferative phase. Despite an improved understanding of ARDS pathobiology, our ability to predict the development of ARDS and risk-stratify patients with the disease remains limited. Biomarkers may help to identify patients at the highest risk of developing ARDS, assess response to therapy, predict outcome, and optimize enrollment in clinical trials. After a short description of ARDS pathobiology, here, we review the scientific evidence that supports the value of various ARDS biomarkers with regard to their major biological roles in ARDS-associated lung injury and/or repair. Ongoing research aims at identifying and characterizing novel biomarkers, in order to highlight relevant mechanistic explorations of lung injury and repair, and to ultimately develop innovative therapeutic approaches for ARDS patients. This review will focus on the pathophysiologic, diagnostic, and therapeutic implications of biomarkers in ARDS and on their utility to ultimately improve patient care.