Localisation of malignant glioma by a radiolabelled human monoclonal antibody.
Localisation of malignant glioma by a radiolabelled human monoclonal antibody.
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通过放射性标记的人单克隆抗体定位恶性神经胶质瘤。
DOI：
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发表时间：
1983
影响因子：
11
通讯作者：
J. Watson
中科院分区：
文献类型：
--
作者：
J. Phillips;T. Alderson;K. Sikora;J. Watson
人单克隆抗体是通过将恶性神经胶质瘤患者的瘤内淋巴细胞与人骨髓瘤系融合而产生的。在筛选与神经胶质瘤细胞系的结合活性后，选择一种抗体进行进一步研究。其来源的患者患有复发性神经胶质瘤。纯化1mg抗体，用131I放射性标记，并静脉内施用。测定血液、脑脊液和肿瘤囊肿液中抗体的分布，并与对照人单克隆免疫球蛋白的分布进行比较。通过外部闪烁扫描观察并证实抗体在肿瘤中的定位。
Human monoclonal antibodies were produced by fusing intratumoral lymphocytes from patients with malignant gliomas with a human myeloma line. One antibody was selected for further study after screening for binding activity to glioma cell lines. The patient from whom it was derived developed recurrent glioma. 1 mg of antibody was purified, radiolabelled with 131I, and administered intravenously. The distribution of antibody was determined in the blood, CSF and tumour cyst fluid and compared with that of a control human monoclonal immunoglobulin. Antibody localisation in the tumour was observed and confirmed by external scintiscanning.
影响因子：
158.5
作者：
MILLER, RA;MALONEY, DG;LEVY, R
通讯作者：
LEVY, R