Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
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作者：
Anthony E. Pegg
多胺的生物合成途径代表了一个诱人的目标，为发展的药物抑制致癌作用和肿瘤生长。多胺在哺乳动物细胞的增殖和发育中起重要作用。多胺代谢紊乱可能是肿瘤发生的重要因素。在体外和动物模型中，多胺的消耗抑制肿瘤细胞的生长。当多胺水平耗尽时，几种不同类别的其他抗癌剂在某些条件下可能发挥增强的作用。目前已有一些合适的多胺生产抑制剂，其他有前途的化合物正在试验中。它应该很快被证明有可能阻止多胺生物合成的每一步的途径。单独使用这些抑制剂以及相互联合或与其他抗肿瘤药物联合使用将能够全面检查这种方法的潜力。
The polyamine-biosynthetic pathway represents an inviting target for the development of agents inhibiting carcinogenesis and tumor growth. Polyamines play an essential role in the proliferation and development of mammalian cells. Deranged polyamine metabolism may be an important factor in carcinogenesis. Depletion of polyamines inhibits growth of neoplastic cells in vitro and in animal models. Several different classes of other anticancer agents may under some conditions exert enhanced effects when polyamine levels are depleted. Some suitable inhibitors of polyamine production are currently available and other promising compounds are presently being tested. It should soon prove possible to block polyamine biosynthesis at every step in the pathway. The use of these inhibitors alone and combined either with each other or with other antitumor agents will enable a full examination of the potential of this approach.