Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis.
Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.1155/2016/6295737
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kwekkeboom KL
中科院分区：
文献类型：
--
作者：
Chen CX;Barrett B;Kwekkeboom KL
这篇系统的综述考察了口服生姜治疗痛经的疗效。检索生物医学数据库和灰色文献。我们纳入了随机对照试验，比较痛经妇女口服生姜与安慰剂或积极治疗的效果。确定了六项试验。两位作者独立审阅了这些文章，提取了数据，并评估了偏倚的风险。通过与第三位审查员达成共识，解决了分歧。我们完成了所有六项研究的叙述性综合，并对三项比较生姜与安慰剂的研究和两项比较生姜与非类固醇消炎药(NSAID)的研究进行了探索性的荟萃分析。生姜在减轻疼痛严重程度方面似乎比安慰剂更有效。10 cm视觉模拟评分的加权平均差值为1.5 5 cm(偏向生姜)(95%CI 0.6 8~2.43)。生姜和甲芬那酸(一种非甾体抗炎药)之间没有显著差异。标化均数差为0(95%可信区间−为0.40~0.41)。现有数据表明，口服生姜可能是治疗痛经月经痛的一种有效方法。然而，研究结果需要谨慎解读，因为研究数量少，研究的方法学质量差，试验之间的异质性很高。这项审查强调了今后进行高方法学质量试验的必要性。
This systematic review examines the efficacy of oral ginger for dysmenorrhea. Key biomedical databases and grey literature were searched. We included randomized controlled trials comparing oral ginger against placebo or active treatment in women with dysmenorrhea. Six trials were identified. Two authors independently reviewed the articles, extracted data, and assessed risk of bias. Discrepancies were resolved by consensus with a third reviewer. We completed a narrative synthesis of all six studies and exploratory meta-analyses of three studies comparing ginger with placebo and two studies comparing ginger with a nonsteroidal anti-inflammatory drug (NSAID). Ginger appeared more effective for reducing pain severity than placebo. The weighted mean difference on a 10 cm visual analogue scale was 1.55 cm (favoring ginger) (95% CI 0.68 to 2.43). No significant difference was found between ginger and mefenamic acid (an NSAID). The standardized mean difference was 0 (95% CI −0.40 to 0.41). Available data suggest that oral ginger could be an effective treatment for menstrual pain in dysmenorrhea. Findings, however, need to be interpreted with caution because of the small number of studies, poor methodological quality of the studies, and high heterogeneity across trials. The review highlights the need for future trials with high methodological quality.