Immune Response of Cholera Patients against the components of Vibrio cholerae
Immune Response of Cholera Patients against the components of Vibrio cholerae
复制标题
霍乱患者对霍乱弧菌成分的免疫反应
DOI：
10.2149/tmh1973.23.227
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
M. Iwanaga
中科院分区：
文献类型：
--
作者：
K. Nakashima;M. Iwanaga
1994年，冲绳爆发了一次零星霍乱。观察霍乱患者对霍乱弧菌的免疫反应，细胞成分和细胞外蛋白。对霍乱毒素和溶血素的反应强烈，而对纯化细胞成分的反应一般较差。虽然抗原不明确，但观察到杀弧菌抗体和细胞凝集抗体明显升高。对热杀伤生物体的凝集滴度只有很小的升高，这表明抗原（凝集素）是细胞表面的热不稳定蛋白。该蛋白抗原的鉴定和纯化将阐明一种霍乱弧菌的保护抗原。
There was a sporadic outbreak of cholera in 1994 in Okinawa. Immune response of the cholera patients against Vibrio cholerae cell components and extracellular proteins were examined. A potent response to cholera toxin and hemolysin, and generally poor response to purified cellular components were seen. Although the antigen was not defined, marked elevation of vibriocidal antibody and cell agglutination antibody was observed. Only little elevation of the agglutination titer against heat-killed organisms suggests that the antigen (agglutinin) is heat labile protein on the cell surface.Identification and purification of this protein antigen will elucidate a protective antigen of V. cholerae.