RAPID AND ACCURATE DETERMINATION OF MEDIAN LETHAL DOSE (LD50) AND ITS ERROR WITH A SMALL COMPUTER
RAPID AND ACCURATE DETERMINATION OF MEDIAN LETHAL DOSE (LD50) AND ITS ERROR WITH A SMALL COMPUTER
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DOI：
10.1080/15287397709529614
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
WOGAN, GN
中科院分区：
文献类型：
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作者：
ROSIELLO, AP;ESSIGMANN, JM;WOGAN, GN
为小型数字计算机编制了计算中位致死剂量（LD50）及其误差的程序。程序中使用的算法是基于Bliss描述的一种方法。还讨论了芬尼提出的修改。结果表明，与布利斯的计算相比，它的精度很高。计算的精度和速度都超过了简化和图解法。介绍了4[2-亚硝基-1-萘酚，1-亚硝基-2-萘酚，2,6-二甲基-4-亚硝基苯酚，对亚硝基苯酚]毒性化合物的数据和结果。
A program for a small digital computer was developed to calculate the median lethal dose (LD50) and its error. The algorithm employed in the program was based on a method described by Bliss. Modifications introduced by Finney are also discussed. The results indicate a high degree of accuracy compared with calculations performed by Bliss. The accuracy and speed of calculation exceeded those possible with simplified and graphic methods. The data and results for 4 [2-nitroso-1-naphthol, 1-nitroso-2-naphthol, 2,6-dimethyl-4-nitrosophenol, p-nitrosophenol] toxic compounds are presented.