Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis
Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis
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DOI：
10.1248/bpb.25.1179
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发表时间：
2002-09-01
影响因子：
2
通讯作者：
But, PPH
中科院分区：
文献类型：
--
作者：
Dai, Y;Chan, YP;But, PPH
本文研究了皂荚异果70%乙醇提取物的抗氧化作用。（AFGS）对实验性过敏反应和炎症的影响。AFGS （200,500, 1000mg /kg, p. o.）剂量依赖性地抑制小鼠化合物48/80引起的全身过敏性休克和大鼠组胺或血清素引起的皮肤反应。在500和1000 mg/kg剂量下，AFGS对大鼠同源被动皮肤过敏反应有明显的抑制作用。在体外，AFGS显著减少化合物48/80在浓度为20和50马克杯/毫升时引发的大鼠腹膜肥大细胞组胺释放。此外，AFGS（500、1000 mg/kg, p. o.）分别对角叉菜胶和巴豆油引起的大鼠后肢水肿和小鼠耳肿胀有显著的抑制作用。在1000 mg/kg剂量下，对醋酸诱导的小鼠血管通透性有明显抑制作用。说明皂荚异常果乙醇提取物具有抗过敏和抗炎活性，其机制可能是通过减少肥大细胞中组胺等介质的释放，减弱这些介质的炎症作用。
This study was carried out to determine the effects of the 70% ethanolic extract from the anomalous fruits of Gleditsia sinensis LAM. (AFGS) on experimental allergic reactions and inflammation. AFGS (200, 500, 1000 mg/kg, p. o.) dose-dependently inhibited the systemic anaphylactic shock induced by compound 48/80 in mice and cutaneous reactions induced by histamine or serotonin in rats. At doses of 500 and 1000 mg/kg, AFGS showed a clear inhibition on homologous passive cutaneous anaphylaxis in rats. In vitro, AFGS significantly reduced histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 20 and 50 mug/ml. Moreover, AFGS (500, 1000 mg/kg, p. o.) showed a significant inhibition on the hind paw edema in rats and ear swelling in mice caused by carrageenin and croton oil, respectively. It also clearly inhibited the vascular permeability induced by acetic acid in mice at a dose of 1000 mg/kg. These findings demonstrate that the ethanolic extract from the anomalous fruits of Gleditsia sinensis possesses antiallergic and anti-inflammatory activities, which may be mediated by reducing the release of mediators such as histamine from mast cells and weakening the inflammatory action of these mediators.