Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.
Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.
复制标题
在系列化合物中训练的微量调节的胆碱能调节：发育分析。
DOI：
10.1016/j.nlm.2006.05.001
复制
发表时间：
2006
影响因子：
2.7
通讯作者：
Baker,EricM
中科院分区：
文献类型：
--
作者：
Hunt,PamelaS;Barnet,RobertC;Shea,MeghanE;Baker,EricM
在四个实验中，系列复合条件反射的影响，以应对一个跟踪条件CS进行了评估使用恐惧条件反射范式。受试者是18天和25天大的Sprague-Dawley大鼠，以前显示出很少或没有痕量的恐惧条件反射。在这里，18日龄的动物被证明能够在视觉CS 1和电击US之间进行跟踪条件反射，前提是在连续条件反射试验（CS 1 →CS2→US）期间跟踪间隔充满非目标CS2。探索胆碱能机制参与微量和系列条件反射，额外的实验评估条件反射训练前管理的毒蕈碱受体拮抗剂东莨菪碱。无论受试者是否接受标准描记（CS 1 →描记间隔→US）或系列（CS 1 →CS2→US）试验的训练，东莨菪碱对描记CS 1的反应均产生剂量依赖性降低。对CS2的反应不受东莨菪碱的影响。这些数据表明，中央胆碱能系统的功能，在年轻的动物，但通常没有充分激活的标准痕量条件反射程序。结果表明，串行复合条件反射可以促进跟踪条件反射在年轻的大鼠，因为它在成年人，也许是通过增强胆碱能活性在训练过程中。后期个体发育出现的痕迹空调的影响，因为它涉及到成熟的神经通路和它们的作用，在增强的差距填充物的影响进行了讨论。
In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague–Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age were shown to be capable of trace conditioning between a visual CS1 and a shock US, provided the trace interval was filled with a non-target CS2 during serial conditioning trials (CS1→CS2→US). To explore cholinergic mechanisms involved in trace and serial conditioning, additional experiments assessed conditioned responding following pre-training administration of the muscarinic receptor antagonist scopolamine. Scopolamine produced a dose-dependent reduction in responding to the trace CS1, regardless of whether subjects were trained with standard trace (CS1→trace interval→US) or serial (CS1→CS2→US) trials. Responding to CS2 was unaffected by scopolamine. These data suggest that central cholinergic systems are functional in the young animals, but are not normally sufficiently activated by standard trace conditioning procedures. The results suggest that serial compound conditioning can promote trace conditioning in young rats, as it does in adults, perhaps by enhancing cholinergic activity during training. Implications for the late ontogenetic emergence of trace conditioning as it relates to maturation of neural pathways and their role in the potentiating effects of a gap filler are discussed.