Nucleotide sequences of the three genes coding for human fibrinogen.
Nucleotide sequences of the three genes coding for human fibrinogen.
复制标题
编码人纤维蛋白原的三个基因的核苷酸序列。
DOI：
10.1007/978-1-4615-3806-6_3
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发表时间：
1990
影响因子：
--
通讯作者：
Davie,EW
中科院分区：
文献类型：
--
作者：
Chung,DW;Harris,JE;Davie,EW
纤维蛋白原由肝实质细胞在肝脏中合成并分泌到循环中（1）。纤维蛋白原的肝合成是组成性的，但其速率可由许多生理和非生理因素调节。纤维蛋白原的三条链由来自三个单拷贝基因表达的不同种类的mRNA编码（2，3）。目前的证据表明，人纤维蛋白原的三个基因是连锁的，位于染色体4 q23-q32上延伸约45 kb的区域（4）。基因排列顺序为γ-Aα-Bβ。γ和Aα基因以相同的方向转录，而Bβ基因以相反的方向转录。
Fibrinogen is synthesized in the liver by hepatic parenchymal cells and is secreted into the circulation (1). Hepatic synthesis of fibrinogen is constitutive but the rate can be modulated by a number of physiological and nonphysiological factors. The three chains of fibrinogen are encoded by distinct species of mRNA that are derived from the expression of three single copy genes (2, 3). Present evidence indicates that the three genes of human fibrinogen are linked and are located in a region that extends approximately 45 kb on chromosome 4q23-q32 (4). The genes are arranged in the order of γ-Aα-Bβ. The γ and Aα genes are transcribed in the same direction while the Bβgene is transcribed in the opposite direction.