Regular exercise-induced increased number and activity of circulating endothelial progenitor cells attenuates age-related decline in arterial elasticity in healthy men
Regular exercise-induced increased number and activity of circulating endothelial progenitor cells attenuates age-related decline in arterial elasticity in healthy men
复制标题
定期运动引起的循环内皮祖细胞数量和活性增加可减轻健康男性与年龄相关的动脉弹性下降
DOI：
10.1016/j.ijcard.2011.08.055
复制
发表时间：
2013-05-10
影响因子：
3.5
通讯作者：
Tao, Jun
中科院分区：
文献类型：
--
作者：
Yang, Zhen;Xia, Wen-Hao;Tao, Jun
背景：随着年龄的增长，循环内皮祖细胞数量和活性的不足与动脉弹性的降低有关。体育锻炼可以增加人体循环EPCs的数量和活性。在这里，我们调查是否定期运动诱导的增强循环内皮祖细胞（EPCs）提高年龄相关的动脉弹性下降在healthyman.Methods：在一项横断面研究中，循环内皮祖细胞的数量和活动，以及臂踝脉搏波速度（baPWV）的年轻人和老年人久坐不动或运动训练的健康男性进行了研究。结果：无论是久坐还是运动训练，老年人循环EPCs的数量和活性均明显低于年轻人，这与baPWV的增加有关。经过三个月的定期运动，循环EPCs的数量和活性增加，10名老年人和10名年轻人久坐的健康男性的baPWV下降。然而，增加的数量和活动的循环EPCs和减少baPWV的老年久坐的健康男性更高。循环EPCs与baPWV密切相关。多变量分析确定增殖活性循环内皮祖细胞作为一个独立的预测baPWV.Conclusions：本研究首次表明，定期体育锻炼引起的增强循环内皮祖细胞衰减年龄相关的动脉弹性下降在健康男性。这些发现为运动对年龄相关性血管损伤的保护作用提供了新的见解。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Background: Deficiency in number and activity of circulating EPCs is associated with reduced arterial elasticity in humans with advancing aging. Physical exercise can increase the number and activity of circulating EPCs in humans. Here we investigated whether regular exercise-induced enhanced circulating endothelial progenitor cells (EPCs) improves age-related decline in arterial elasticity in healthy men.Methods: In a cross-sectional study, the number and activity of circulating EPCs as well as brachial-ankle pulse wave velocity (baPWV) of young and older sedentary or endurance-trained healthy men were studied. Then we observed the effect of regular exercise on circulating EPCs and baPWV of 10 older and 10 young sedentary healthy men.Results: In both sedentary and endurance-trained men, the number and activity of circulating EPCs were significantly low in older men compared with young men, which was paralleled to increased baPWV. After three months of regular exercise, the number and activity of circulating EPCs increased, and the baPWV of 10 older and 10 young sedentary healthy men decreased. However, the increased number and activity of circulating EPCs and decreased baPWV of older sedentary healthy men were higher. There was a close correlation between circulating EPCs and baPWV. Multivariate analysis identified proliferative activity of circulating EPCs as an independent predictor of baPWV.Conclusions: The present study demonstrates for the first time that regular physical exercise-induced enhanced circulating EPCs attenuates age-related decline in arterial elasticity in healthy men. These findings provide novel insights into the protective effects of exercise on age-related vascular injury. (C) 2011 Elsevier Ireland Ltd. All rights reserved.