Use of antihypertensive drugs and risk of skin cancer
Use of antihypertensive drugs and risk of skin cancer
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DOI：
10.1111/jdv.12921
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发表时间：
2015-08-01
影响因子：
9.2
通讯作者：
Sorensen, H. T.
中科院分区：
文献类型：
--
作者：
Schmidt, S. A. J.;Schmidt, M.;Sorensen, H. T.
目的探讨抗高血压药物的使用是否与鳞状细胞癌（SCC）、基底细胞癌（BCC）和恶性黑色素瘤（MM）有关。方法我们采用基于人群的数据库进行病例对照研究，包括所有首次发病的SCC（n=2282）、BCC（n=17242）、HCC（n=17242）和HCC（n=17242）。和MM（n=3660）在北方丹麦，1991-2010年。我们匹配了大约10个对照组（n=231743），每个病例的年龄，性别和县使用风险集抽样。我们使用条件Logistic回归计算皮肤癌的比值比（OR），95%置信区间比较既往使用抗高血压药物（>2次既往处方）和非使用者（2次既往处方）。我们调整了合并症和合并症。我们进一步分析了持续时间（短期：
BackgroundSeveral antihypertensive drugs are photosensitizing and may therefore act as cocarcinogens with ultraviolet radiation.ObjectiveTo examine whether antihypertensive drug use is associated with squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and malignant melanoma (MM).MethodsWe used population-based databases to conduct a case-control study including all first-time cases of SCC (n=2282), BCC (n=17242), and MM (n=3660) in northern Denmark, 1991-2010. We matched approximately 10 controls (n=231743) to each case by age, sex and county using risk-set sampling. We used conditional logistic regression to compute odds ratios (ORs) for skin cancer with 95% confidence intervals comparing ever users of antihypertensives (>2 previous prescriptions) with non-users (2 previous prescriptions). We adjusted for comorbidity and comedications. We further analysed use by duration (short term: