Effect of dietary. beta. -carotene, vitamin A and selenium on formation of preneoplastic lesions in rat liver

Effect of dietary. beta. -carotene, vitamin A and selenium on formation of preneoplastic lesions in rat liver
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饮食的影响。

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发表时间：
1986
期刊：
影响因子：
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通讯作者：
R. Parker
R. Parker
中科院分区：
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文献类型：
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作者：
J. Colford;R. Parker

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饮食的影响贝塔.. -胡萝卜素（BC）、醋酸视黄酯（RA）和亚硒酸钠对..伽马.. -研究了大鼠肝脏中谷氨酰转肽酶阳性病灶。将50 g的雄性Sprague-Dawley大鼠喂食补充有BC（500 mg/kg饮食）、RA（第1-7周6400 IU/kg饮食和第8-16周10，000 IU/kg饮食）、1.8 ppm硒（Se）或1.8 ppm Se和500 mg/kg BC两者的半纯化饮食16周。对照组日粮含0.1ppm硒和3200 IU RA/kg日粮。在第3-4周期间，大鼠接受10次黄曲霉毒素B/sub 1/（0.4 mg/kg体重/剂）胃内给药。在第16周定量肿瘤前病灶。饮食对生长速度或摄食量无显著影响。所有处理均未导致每cm/sup 2/肝切片的病灶数量存在显著差异，但病灶大小存在差异。RA增加总病灶面积（mm/sup 2//cm/sup 2/肝），而Se减少病灶面积5倍。BC轻微缩小了病灶面积。BC和Se的组合不如Se单独有效。BC，RA和BC-Se饮食产生的总肝脏视黄醇水平相当，超过对照组和硒大鼠的水平30倍。来自BC喂养的大鼠的肝脏含有4-5. Mu.. g BC/g肝脏。饮食RA和BC对焦点发展的不同影响可能表明BC的作用，而不是作为视黄醇前体。每种营养素对病灶大小的影响，而不是数量，意味着它们在病灶发育的启动后阶段起作用。«少
The effect of dietary ..beta..-carotene (BC), retinyl acetate (RA) and sodium selenite on formation of ..gamma..-glutamyltranspeptidase-positive foci in rat liver was investigated. Male Sprague-Dawley rats, 50g, were fed for 16 wks semipurified diets supplemented with either BC (500 mg/kg diet), RA (6400 IU/kg diet for wks 1-7 and 10,000 IU/kg for wks 8-16), 1.8 ppm selenium (Se) or both 1.8 ppm Se and 500 mg/kg BC. The control diet contained 0.1 ppm Se and 3200 IU RA/kg diet. During wks 3-4 rats received 10 intragastric doses of aflatoxin B/sub 1/ (0.4 mg/kg body weight/dose). Preneoplastic foci were quantitated at wk 16. Diet had no significant effect on growth rate or food consumption. None of the treatments resulted in significant differences in the number of foci per cm/sup 2/ liver section, but differences in focal size occurred. RA increased total focal area (mm/sup 2//cm/sup 2/ liver), while Se decreased focal area 5-fold. BC slightly decreased focal area. The combination of BC and Se was not as effective as Se alone. BC, RA, and BC-Se diets yielded equivalent levels of total liver retinol, which exceeded levels in control and Se rats by 30-fold. Livers from BC fed rats contained 4-5 ..mu..g BC/gmore » liver. The different effects of dietary RA and BC on focal development may indicate a role for BC other than as a retinol precursor. The influence of each nutrient on focal size, but not number, implies they act during the post-initiation stage of focal development.« less