Toward the development of an artificial cornea: Improved stability of interpenetrating polymer networks
Toward the development of an artificial cornea: Improved stability of interpenetrating polymer networks
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DOI：
10.1002/jbm.b.31806
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发表时间：
2011-07-01
影响因子：
3.4
通讯作者：
Frank, Curtis W.
中科院分区：
文献类型：
--
作者：
Hartmann, Laura;Watanabe, Kenji;Frank, Curtis W.
研制了一种新型的聚乙二醇聚丙烯酸互穿网络(IPN)，并在体内评价了其作为人工角膜的应用。第一组基于聚乙二醇二丙烯酸酯前体的角膜嵌体的体内结果显示，治疗后的眼睛发炎，角膜混浊。生物相容性的不足可能与随着时间的推移而导致的水解性降解导致的植入物的长期稳定性差有关。通过用稳定的丙烯酰胺官能团取代可水解的丙烯酸酯官能团来调整水凝胶的化学结构，可以提高所得互穿聚合物网络在水解条件下的长期稳定性。这套新的水凝胶植入物现在在体内显示出更好的生物相容性。植入角膜植入物的兔是健康的，植入后6个月内角膜透明，眼部无炎症。(C)2011年威利期刊公司J生物材料资源B部分：APPL生物材料98B：8-17,2011。
A novel interpenetrating network (IPN) based on poly(ethylene glycol) (PEG) and poly(acrylic acid) was developed and its use as an artificial cornea was evaluated in vivo. The in vivo results of a first set of corneal inlays based on PEG-diacrylate precursor showed inflammation of the treated eyes and haze in the corneas. The insufficient biocompatibility could be correlated to poor long-term stability of the implant caused by hydrolytic degradation over time. Adapting the hydrogel chemistry by replacing hydrolysable acrylate functionalities with stable acrylamide functionalities was shown to increase the long-term stability of the resulting IPNs under hydrolytic conditions. This new set of hydrogel implants now shows increased biocompatibility in vivo. Rabbits with corneal inlay implants are healthy and have clear cornea and non-inflamed eyes for up to 6 months after implantation. (c) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 98B: 8-17, 2011.