Estimating the impact of prehistoric admixture on the genome of Europeans
Estimating the impact of prehistoric admixture on the genome of Europeans
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DOI：
10.1093/molbev/msh135
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发表时间：
2004-07-01
影响因子：
10.7
通讯作者：
Barbujani, G
中科院分区：
文献类型：
--
作者：
Dupanloup, I;Bertorelle, G;Barbujani, G
我们推断过去的混合过程中，在欧洲人口的遗传多样性在8个位点，包括常染色体，线粒体和Y连锁多态性。混合系数估计从多位点数据，假设大多数目前的人口可以被视为四个或更少的潜在的亲本群体之间的杂交过程的结果。在欧洲人的基因组中有两个主要的组成部分，大概与第一批旧石器时代的欧洲人和早期从近东分散的新石器时代农民的贡献相对应。此外，只有一小部分欧洲等位基因似乎来自北非，反映来自北方亚洲的基因流动的第四个成分主要限于该大陆的东北部。随着从东向西移动，估计的近东贡献减少，与来自近东的（新石器时代）移民在当前欧洲人基因组中贡献了很大份额的等位基因的模型的预测一致。几个测试表明，可能偏离混合模型，由于因素，如选择假定的父母人口和更复杂的人口情况下，可能会影响我们的主要估计只有在有限的程度上。
We inferred past admixture processes in the European population from genetic diversity at eight loci, including autosomal, mitochondrial and Y-linked polymorphisms. Admixture coefficients were estimated from multilocus data, assuming that most current populations can be regarded as the result of a hybridization process among four or less potential parental populations. Two main components are apparent in the Europeans' genome, presumably corresponding to the contributions of the first, Paleolithic Europeans, and of the early, Neolithic farmers dispersing from the Near East. In addition, only a small fraction of the European alleles seems to come from North Africa, and a fourth component reflecting gene flow from Northern Asia is largely restricted to the northeast of the continent. The estimated Near Eastern contribution decreases as one moves from east to west, in agreement with the predictions of a model in which (Neolithic) immigrants from the Near East contributed a large share of the alleles in the genome of current Europeans. Several tests suggest that probable departures from the admixture models, due to factors such as choice of the putative parental populations and more complex demographic scenarios, may have affected our main estimates only to a limited extent.