Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche
Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche
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DOI：
10.33549/physiolres.934222
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发表时间：
2020-02-01
影响因子：
2.1
通讯作者：
Xu, Rui-Ying
中科院分区：
文献类型：
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作者：
Ge, Wei;Wang, Hai-Lian;Xu, Rui-Ying
本研究旨在调查患有特发性中枢性性早熟（ICPP）和乳房早熟（PT）的女孩的血清makorin环指蛋白3（MKRN3）水平，以确定循环MKRN3水平是否与ICPP和PT相关。共有 90 名女孩参加了这项研究。每组分配 30 名年龄匹配的女孩（分别为 ICPP、PT 和健康对照 [HC]）。 ICPP 女孩的基础 LH (B-LH) 和 E2 水平高于 HC 和 PT 女孩。 ICPP女孩的LH峰值（P-LH）水平和P-LH/P-FSH值明显高于PT女孩，而PT女孩的峰值FSH（P-FSH）水平高于ICPP女孩。 HC 女孩的 Kisspeptin 水平低于 ICPP 和 PT 女孩。三组中 HC 女孩的 MKRN3 水平最高。 MKRN3、Kisspeptin和P-LH/P-FSH之间存在较强的负相关关系。循环中的 MKRN3 在 ICPP 和 PT 的发生中发挥重要作用。然而，这不应用作诊断ICPP或区分ICPP与PT的独立诊断标准，而应仅用作辅助诊断生物标志物。
This study aims to investigate serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty (ICPP) and premature thelarche (PT), in order to determine whether circulating MKRN3 level is associated with ICPP and PT. A total of 90 girls were enrolled in the study. 30 age-matched girls were allocated for each group (ICPP, PT and healthy controls [HC], respectively). The base LH (B-LH) and E2 levels were higher in ICPP girls than those in HC and PT girls. The peak LH (P-LH) levels and P-LH/P-FSH values were obviously higher in ICPP girls than those in PT girls, while higher peak FSH (P-FSH) levels were detected in PT girls when compared to those in ICPP girls. Kisspeptin levels were lower in HC girls than those in ICPP and PT girls. MKRN3 levels were the highest in HC girls among the three groups. There were relatively strong negative correlations among MKRN3, kisspeptin and P-LH/P-FSH. Circulating MKRN3 can have an important role in the onset of ICPP and PT. However, this should not be used as an independent diagnostic criterion for diagnosing ICPP or differentiating ICPP from PT, but should be used only as an adjunctive diagnostic biomarker.