A multicenter study on the prevalence of diabetic neuropathy in Italy
A multicenter study on the prevalence of diabetic neuropathy in Italy
复制标题
DOI：
10.2337/diacare.20.5.836
复制
发表时间：
1997-05-01
期刊：
影响因子：
16.2
通讯作者：
Lanzetti, AM
中科院分区：
文献类型：
--
作者：
Fedele, D;Comi, G;Lanzetti, AM
目的-神经病变的患病率，糖尿病的常见并发症，在糖尿病患者招募从109个糖尿病门诊诊所在意大利.研究设计和方法-神经病变的诊断使用糖尿病神经病变指数（DNI），标准化的检查开发用于在门诊设置。共有8，757名糖尿病患者接受了研究，其中51.2%为男性，48.8%为女性，平均年龄和中位年龄分别为56岁和58岁。结果-在8，757名患者中，32.3%患有神经病变，定义为DNI阳性评分>2分。共有2,033人（49.6%男性和50.4%女性）接受了神经科医生的糖尿病神经病变评分（DNS），这是筛查计划的第二部分。该部分包括定量神经学检查和神经传导研究，共同提供总分。共有335例患者（16.5%）为非神经病性，395例（19.4%）为临界神经病，453例（22.3%）为轻度神经病，592例（29.1%）为中度神经病，258例（12.7%）为重度神经病。DNI阳性评分与DNS提示神经病变的一致性为83.5%。神经病变的严重程度随着年龄和病程的增加而增加。在神经病变患者中，64.1%的患者平均年龄在58 - 59岁之间，病程在12.4 +/- 8.4年（轻度神经病变）和15.6 +/- 9.7年（重度神经病变）之间。提高对神经病高患病率的认识可以导致早期治疗干预和可能预防后期神经病并发症，如感染和足部溃疡。
OBJECTIVE - The prevalence of neuropathy, a common complication of diabetes, was determined in diabetic patients recruited from 109 outpatient diabetes clinics in Italy.RESEARCH DESIGN AND METHODS - Neuropathy was diagnosed using the Diabetic Neuropathy Index (DNI), a standardized examination developed for use in the outpatient setting. A total of 8,757 diabetic patients were studied, 51.2% men and 48.8% women, with average and median ages of 56 and 58 years, respectively.RESULTS - Of the 8,757 patients, 32.3% had neuropathy, defined as a positive score of >2 points on the DNI. A total of 2,033 (49.6% men and 50.4% women) were administered the Diabetic Neuropathy Score (DNS), the second component of the screening program, by a neurologist. This component consists of a quantitative neurological examination and nerve conduction studies that together provide a summated score. A total of 335 patients (16.5%) were not neuropathic, and 395 (19.4%) had borderline, 453 (22.3%) mild, 592 (29.1%) moderate, and 258 (12.7%) severe neuropathy. The concordance between a positive score on the DNI and a DNS indicating neuropathy was 83.5%. The severity of neuropathy increased with both age and disease duration. Of patients with neuropathy, 64.1% had an average age between 58 and 59 years with a disease duration between 12.4 +/- 8.4 years (mild neuropathy) and 15.6 +/- 9.7 years (severe neuropathy).CONCLUSIONS - Neuropathy is a common complication of diabetes and, in this study, was present in 32.3% of all patients. An increased awareness of the high prevalence of neuropathy can lead to early therapeutic intervention and possible prevention of later neuropathic complications, such as infection and foot ulcers.