OXYGEN DEPLETION IN CELLS IRRADIATED AT ULTRAHIGH DOSE-RATES AND AT CONVENTIONAL DOSE-RATES
OXYGEN DEPLETION IN CELLS IRRADIATED AT ULTRAHIGH DOSE-RATES AND AT CONVENTIONAL DOSE-RATES
复制标题
DOI：
10.1080/09553007414550901
复制
发表时间：
1974-01-01
影响因子：
2.6
通讯作者：
SANTOMASSO, A
中科院分区：
文献类型：
--
作者：
WEISS, H;EPP, ER;SANTOMASSO, A
在密封容器中以常规剂量率照射氧平衡的细菌细胞悬浮液可产生破裂的存活曲线，类似于以超高剂量率以薄层形式照射的细胞的存活曲线。该实验室以前建立的一个数学模型也产生了断裂的存活曲线，并与在两种剂量率下测量的存活分数进行了比较。这种比较在两个极端产生了对溶解氧的放化耗竭速率和因数K的测定，K是指放射敏感性介于缺氧值和完全氧气值之间的氧浓度。发现油墨存在剂量率依赖关系。对于密封容器，耗尽率的测定与用氧电极直接测定的结果基本一致。该协议支持了断电行为是由于氧气耗尽的断言。
Irradiation at conventional dose-rates of an oxygen-equilibrated bacterial cell suspension in a sealed vessel produces breaking survival curves similar to those observed for cells irradiated as a thin layer at ultra-high dose-rates. A mathematical model previously derived by this laboratory, which also yields breaking survival curves, is compared with the surviving fraction measured at both dose-rates. This comparison yields, at the two extremes, determinations of the rate of radiochemical depletion of dissolved oxygen and of the factorK, the oxygen concentration at which the radiosensitivity is halfway between the anoxic and fully oxygenated values. It is found that there is a dose-rate dependence inK. For the sealed vessel, the determination of the rate of depletion is in essential agreement with that measured directly with an oxygen electrode. The agreement supports the assertion that the breaking behaviour is due to oxygen depletion.