Analytical quantification of aortic valve 18F-sodium fluoride PET uptake
Analytical quantification of aortic valve 18F-sodium fluoride PET uptake
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DOI：
10.1007/s12350-018-01542-6
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发表时间：
2020-06-01
影响因子：
2.4
通讯作者：
Slomka, Piotr J.
中科院分区：
文献类型：
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作者：
Massera, Daniele;Doris, Mhairi K.;Slomka, Piotr J.
背景心脏PET-CT面临的挑战包括患者运动、长时间的图像采集和由于门控而导致的计数减少。我们比较了两种分析工具，FusionQuant和OsiriX，用于量化门控心脏18F-氟化钠(18F-氟化钠)PET-CT成像。方法27例主动脉瓣狭窄患者，其中15例相隔4周复查。使用Bland-Altman方法和林氏一致性相关系数(CCC)确定分析工具与扫描-再扫描重复性之间的一致性。结果FusionQuant的图像分析速度[中位时间(IQR)7：10(6：40-8：20)分钟]明显快于OsiriX[8：30(8：00-10：10)分钟，p=0.002]。不同计划之间摄取测量的一致性很好，平均组织与背景比(TBRean)的ccc=0.972(95%可信区间0.949-0.995)，最大组织背景比(TBRmax)的0.981(95%可信区间0.965-0.997)。平均噪声从舒张门的11.7%下降到运动校正图像的6.7%(p=0.002)；信噪比从25.41增加到41.13(p=0.0001)。与OsiriX相比，使用运动校正的FusionQuant改善了TBR(Max)的主动脉瓣扫描-再扫描重复性(误差+/-36%vs+/-13%，p<；.001)，而TBR(Mean)的重复性相似(+/-10%vs+/-8%，p=.252)。结论FusionQuant与OsiriX的18F-氟PET定量结果具有可比性。FusionQuant具有运动校正功能，在分析时间和TBR(最大)值的重复性方面具有优势。
Background Challenges to cardiac PET-CT include patient motion, prolonged image acquisition and a reduction of counts due to gating. We compared two analytical tools, FusionQuant and OsiriX, for quantification of gated cardiac 18F-sodium fluoride (18F-fluoride) PET-CT imaging. Methods Twenty-seven patients with aortic stenosis were included, 15 of whom underwent repeated imaging 4 weeks apart. Agreement between analytical tools and scan-rescan reproducibility was determined using the Bland-Altman method and Lin's concordance correlation coefficients (CCC). Results Image analysis was faster with FusionQuant [median time (IQR) 7:10 (6:40-8:20) minutes] compared with OsiriX [8:30 (8:00-10:10) minutes,p = .002]. Agreement of uptake measurements between programs was excellent, CCC = 0.972 (95% CI 0.949-0.995) for mean tissue-to-background ratio (TBRmean) and 0.981 (95% CI 0.965-0.997) for maximum tissue-to-background ratio (TBRmax). Mean noise decreased from 11.7% in the diastolic gate to 6.7% in motion-corrected images (p = .002); SNR increased from 25.41 to 41.13 (p = .0001). Aortic valve scan-rescan reproducibility for TBR(max)was improved with FusionQuant using motion correction compared to OsiriX (error +/- 36% vs +/- 13%,p < .001) while reproducibility for TBR(mean)was similar (+/- 10% vs +/- 8%p = .252). Conclusion 18F-fluoride PET quantification with FusionQuant and OsiriX is comparable. FusionQuant with motion correction offers advantages with respect to analysis time and reproducibility of TBR(max)values.