Antiemetic medications in pregnancy: a prospective investigation of obstetric and neurobehavioral outcomes.
Antiemetic medications in pregnancy: a prospective investigation of obstetric and neurobehavioral outcomes.
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DOI：
10.1016/j.ajog.2014.01.005
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发表时间：
2014-03
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
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The study goal was to examine the impact of commonly prescribed antiemetic medications in pregnancy on neurobehavioral and obstetrical outcomes. 533 women accounting for 550 live births (17 multiple gestations) enrolled prior to 16 weeks gestation participating in an observational longitudinal study of stress and pharmacological exposure in pregnancy at Emory Women’s Mental Health Program (WMHP) were included in this study. Maternal report of exposure to medications was documented by weeks of use. Obstetrical and neonatal data were obtained from medical records. The Brazelton Neurobehavioral Assessment Scale (NBAS) was completed by certified raters at age 7 days. The Child Behavior Check List (CBCL) was completed by the mother between 17 and 66 months of age. Comparison of groups was conducted utilizing chi-square and Wilcoxon rank-sum tests. Spearman correlation analysis was used for CBCL percentile scores to evaluate duration of exposure. The exposed group (n=143) was comprised of children whose mothers received promethazine or ondansetron during pregnancy. Unexposed children (n=407) were utilized for comparison. NBAS data 7 days (range 2–77) was available on 345 infants (exposed n=102; unexposed n=243), and a total of 247 CBCLs (exposed n=51; unexposed n=196) at 29 (range 17–66) months of age. No significant differences were seen using NBAS and CBCL. Statistically significant differences were seen in gestational age at delivery (0.3 weeks) and birth weight (110 grams). No clinically significant adverse neurobehavioral effects or obstetrical outcomes were identified. This is reassuring as promethazine and ondansetron are commonly prescribed during pregnancy. A prospective investigation of the impact of antiemetic medications in pregnancy on obstetrical and neurobehavioral outcomes
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DOI：
10.1016/j.ejogrb.2013.04.017
发表时间：
2013-09-01
影响因子：
2.6
作者：
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Johnson KC;LaPrairie JL;Brennan PA;Stowe ZN;Newport DJ
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通讯作者：
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