Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them.
Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them.
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DOI：
10.3389/fphar.2013.00168
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发表时间：
2014
影响因子：
5.6
通讯作者：
Molnar J
中科院分区：
文献类型：
--
作者：
Amaral L;Martins A;Spengler G;Molnar J
本文讨论了革兰氏阴性菌的外排泵系统与细菌的其他耐药机制，如群体感应、生物被膜、双组分调节等的关系，并讨论了革兰氏阴性菌对抗生素的遗传反应，使其对抗生素产生免疫。最后，详细介绍了已开发的鉴定过表达其EP系统的细菌的方法。吩噻嗪是一种广为人知的抗精神病药物，据报道具有抗细菌EPs和其他生物体辅助抗生素机制的活性。因此，这些化合物也将被讨论。
This review discusses the relationship of the efflux pump (EP) system of Gram-negative bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing, biofilms, two component regulons, etc. The genetic responses of a Gram-negative to an antibiotic that render it immune to an antibiotic are also discussed. Lastly, the methods that have been developed for the identification of bacteria that over-express their EP system are presented in detail. Phenothiazines are well-known antipsychotic drugs with reported activity against bacterial EPs and other ancillary antibiotic mechanisms of the organism. Therefore these compounds will also be discussed.
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影响因子：
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作者：
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