Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis.
Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis.
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DOI：
10.1080/00365517709091498
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发表时间：
1977-09
影响因子：
2.1
通讯作者：
H. Link;G. Tibbling
中科院分区：
文献类型：
--
作者：
H. Link;G. Tibbling
通过测定CSF蛋白和CSF/S白蛋白比值，对59例多发性硬化症患者的血脑屏障功能进行了研究。异常值分别为19%和32%。通过测定CSF IgG/protein和CSF IgG/albumin比值及IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio)分析CSF-IgG在CNS内合成升高的发生。增加值分别为75%、80%和86%。琼脂糖凝胶电泳在88%的患者脑脊液中检出寡克隆IgG。IgG指数是推荐用于证明由于中枢神经系统内合成而导致CSF中IgG升高的参数。
Fifty-nine multiple sclerosis patients were investigated with regard to blood-brain barrier function by determining the CSF-protein and the CSF/S albumin ratio. Abnormal values were found in 19% and 32% respectively. The occurrence of CSF-IgG elevation due to synthesis within the CNS was analysed by determining the CSF IgG/protein and CSF IgG/albumin ratios and the IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio). Increased values were found in 75%, 80% and 86%, respectively. Oligoclonal IgG was found in CSF by agarose gel electrophoresis in 88% of the patients. The IgG-index is the parameter recommended for the demonstration of an IgG elevation in CSF due to synthesis within the CNS.