A Potent Hypotensive Peptide, Novokinin, Induces Relaxation by AT2- and IP-Receptor-Dependent Mechanism in the Mesenteric Artery from SHRs
A Potent Hypotensive Peptide, Novokinin, Induces Relaxation by AT2- and IP-Receptor-Dependent Mechanism in the Mesenteric Artery from SHRs
复制标题
DOI：
10.1271/bbb.70638
复制
发表时间：
2008-01
期刊：
影响因子：
--
通讯作者：
Yuko Yamada;D. Yamauchi;Megumi Yokoo;Kousaku Ohinata;H. Usui;M. Yoshikawa
中科院分区：
文献类型：
--
作者：
Yuko Yamada;D. Yamauchi;Megumi Yokoo;Kousaku Ohinata;H. Usui;M. Yoshikawa
在本研究中，我们发现，novokinin（Arg-Pro-Leu-Lys-Pro-Trp），一种通过AT 2受体起作用的强效舒张肽，在自发性高血压大鼠的肠系膜动脉中具有血管舒张活性。血管舒张活性被PD 123319、吲哚美辛和CAY 10441显著阻断，它们分别是AT 2受体拮抗剂、环氧合酶抑制剂和IP受体拮抗剂。一氧化氮合酶抑制剂N G-硝基-L-精氨酸甲酯并不阻断血管舒张活性。这些结果表明，novokinin的血管舒张活性，这有助于扩张作用，主要是由前列腺素I2（前列环素）和IP受体下游的AT 2受体介导的。
In this study, we found that novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent hypotensive peptide acting through the AT2 receptor, has vasorelaxing activity in the mesenteric artery isolated from spontaneously hypertensive rats. The vasorelaxing activity was significantly blocked by PD123319, indomethacin, and CAY10441, which are an AT2 receptor antagonist, a cyclooxygenase inhibitor, and an IP receptor antagonist, respectively. N G-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, did not block the vasorelaxing activity. These results suggest that the vasorelaxing activity of novokinin, which contributes to the hypotensive effect, is mainly mediated by prostaglandin I2 (prostacyclin) and the IP receptor downstream of the AT2 receptor.