T cells and IL-17 in lupus nephritis.
T cells and IL-17 in lupus nephritis.
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DOI：
10.1016/j.clim.2016.04.010
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Tsokos GC
中科院分区：
文献类型：
--
作者：
Koga T;Ichinose K;Tsokos GC
系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病，其特征是自身抗体的产生、免疫复合体的形成和免疫调节失调，导致包括肾脏在内的多个器官的损害。狼疮性肾炎(LN)是SLE最常见的严重表现，累及大多数患者。尽管有大量研究表明白介素17(IL-17)和Th17细胞在LN的发病机制中起重要作用，但LN发生发展的确切分子机制尚未完全阐明。本文就系统性红斑狼疮患者T细胞和IL-17细胞的一般特征作一综述。此外，我们还详细讨论了控制狼疮肾病患者和狼疮易感小鼠肾小球肾炎中IL-17产生的T细胞信号通路。更好地了解LN中的信号和基因调节缺陷将有助于识别新的治疗靶点和预测该疾病的诊断和预后的生物标志物。
Systemic lupus erythematosus (SLE) is a complicated autoimmune disorder characterized by autoantibodies production, immune complex formation, and immune dysregulation, resulting in damage of multiple organs including the kidney. Lupus nephritis (LN) is the most common severe manifestation of SLE involving the majority of patients. Even though there are a number of reports indicating that interleukin-17 (IL-17) and Th17 cells play important roles in the pathogenesis of LN, the precise molecular mechanisms underline the development of LN have not been totally elucidated. In this review, we briefly summarize general characteristics of T and IL-17 cells in SLE. In addition, we discuss in detail T cell signaling pathways which control IL-17 production in patients with LN and in glomerulonephritis in lupus-prone mice. A better understanding of signaling and gene regulation defects in LN will lead to the identification of novel therapeutic targets and predictive biomarkers for diagnosis and prognosis of this disease.
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影响因子：
27.4
作者：
Bertsias GK;Tektonidou M;Amoura Z;Aringer M;Bajema I;Berden JH;Boletis J;Cervera R;Dörner T;Doria A;Ferrario F;Floege J;Houssiau FA;Ioannidis JP;Isenberg DA;Kallenberg CG;Lightstone L;Marks SD;Martini A;Moroni G;Neumann I;Praga M;Schneider M;Starra A;Tesar V;Vasconcelos C;van Vollenhoven RF;Zakharova H;Haubitz M;Gordon C;Jayne D;Boumpas DT;European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
通讯作者：
European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
DOI：
10.4049/jimmunol.1200143
发表时间：
2012-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Crispín JC;Apostolidis SA;Rosetti F;Keszei M;Wang N;Terhorst C;Mayadas TN;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
4.4
作者：
Ichinose, Kunihiro;Rauen, Thomas;Tsokos, George C.
通讯作者：
Tsokos, George C.
影响因子：
4.7
作者：
Hahn, Bevra H.;McMahon, Maureen A.;Wilkinson, Alan;Wallace, W. Dean;Daikh, David I.;Fitzgerald, John D.;Karpouzas, George A.;Merrill, Joan T.;Wallace, Daniel J.;Yazdany, Jinoos;Ramsey-Goldman, Rosalind;Singh, Karandeep;Khalighi, Mazdak;Choi, Soo-In;Gogia, Maneesh;Kafaja, Suzanne;Kamgar, Mohammad;Lau, Christine;Martin, William J.;Parikh, Sefali;Peng, Justin;Rastogi, Anjay;Chen, Weiling;Grossman, Jennifer M.
通讯作者：
Grossman, Jennifer M.
影响因子：
4.8
作者：
Apostolidis, Sokratis A.;Rauen, Thomas;Crispin, Jose C.
通讯作者：
Crispin, Jose C.