Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice
Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice
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DOI：
10.1165/ajrcmb.19.5.3457
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发表时间：
1998-11-01
影响因子：
6.4
通讯作者：
Levitt, RC
中科院分区：
文献类型：
--
作者：
McLane, MP;Haczku, A;Levitt, RC
人类特应性哮喘是一种复杂的遗传性气道炎症性疾病，与过敏性炎症和气道高反应性的临床体征相关。最近的研究表明，小鼠肺组织中白细胞介素（IL）-9的表达与气道反应性的程度密切相关。为了研究IL-9对气道高反应性的作用，并直接探讨其与气道炎症的关系，我们研究了过表达IL-9的转基因小鼠。在这份报告中，我们表明，IL-9转基因小鼠（FVB/N-TG 5），与FVB/NJ小鼠相比，显示显着增强嗜酸性粒细胞气道炎症，血清总免疫球蛋白E升高，和气道高反应性肺挑战与天然抗原（烟曲霉菌）。这些数据支持IL-9在过敏性炎症的复杂发病机制中的核心作用。
Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.