Cutting edge:: Nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
Cutting edge:: Nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
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DOI：
10.4049/jimmunol.176.10.5735
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发表时间：
2006-05-15
影响因子：
4.4
通讯作者：
Soler, Paul
中科院分区：
文献类型：
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作者：
Marchal-Somme, Joelle;Uzunhan, Yurdagul;Soler, Paul
次级淋巴组织的异位形成是由初始T和B细胞的局部吸引引发的。在本研究中，我们描述了人类特发性肺纤维化肺中一种新的具有淋巴新生特征的组织化淋巴结构，包括：1）新近活化的CD 40配体（CD 40 L）（+）T细胞，2）数量不等的活化CD 40（+）/CD 40 L（+）B细胞，有时是组织化的小淋巴细胞，3）活化的CD 40（+）/CD 40 L（+）B细胞，4）活化的CD 40（+）/CD 40 L（+）B细胞，5）活化的CD 40（+）/CD 40 L（+）B细胞，5）活化的CD 40（+）/CD 40 L（+）B细胞，6）活化的CD 40（+）/CD 40 L（+）B细胞。3）表达CD 40、CD 83、CD 86和DC-溶酶体相关膜蛋白的完全成熟的树突状细胞（DC）; 4）表达趋化因子CCL 21; 5）存在具有高内皮微静脉特征的血管;和6）致密的滤泡DC网络。令人惊讶的是，这些结构缺乏CCR 7（+）幼稚T细胞、增殖淋巴细胞和增殖中心，这表明新募集的活化DC和Ag经历的淋巴细胞可以驱动淋巴新生，并且淋巴聚集体中存在的因子，如CD 40 L，对诱导DC成熟至关重要。
Ectopic formation of secondary lymphoid tissue is initiated by the local attraction of naive T and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung of human idiopathic pulmonary fibrosis, with key features of lymphoid neogenesis, including: 1) recently activated CD40 ligand (CD40L)(+) T cells; 2) variable numbers of activated CD40(+)/CD40L(+) B cells, sometimes organized injollicles; 3)fully mature dendritic cells (DC) expressing CD40, CD83, CD86, and DC-lysosome-associated membraneprotein; 4) the expression of the chemokine CCL21; 5) the presence of vessels with characteristics of high endothelial venules; and 6) a dense network of follicular DC. Surprisingly, these structures are devoid of CCR7(+) naive T cells, proliferating lymphocytes, andgerminal centers, suggesting that newly recruited activated DC and Ag-experienced lymphocytes can drive lymphoid neogenesis and that factors present within the lymphoid aggregates, such as CD40L, are essential to induce DC maturation.