Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
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DOI：
10.1126/science.288.5475.2379
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发表时间：
2000-06-30
期刊：
影响因子：
56.9
通讯作者：
Kuhajda, FP
中科院分区：
文献类型：
--
作者：
Loftus, TM;Jaworsky, DE;Kuhajda, FP
随着肥胖相关疾病的升级，人们对定义控制食欲和体重的机制产生了极大的兴趣。我们已经确定了合成代谢能量代谢和食欲控制之间的联系。用脂肪酸合酶 (FAS) 抑制剂（浅蓝素和合成化合物 C75）对小鼠进行全身和脑室内治疗，导致进食抑制和体重急剧下降。 C75 抑制下丘脑中前噬信号神经肽 Y 的表达，并以不依赖于瘦素的方式发挥作用，这似乎是由丙二酰辅酶 A 介导的。因此，FAS 可能代表摄食调节中的重要环节，并且可能是潜在的治疗靶点。
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) Led to inhibition of feeding and dramatic weight Loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl-coenzyme A. Thus, FAS may represent an important Link in feeding regulation and may be a potential therapeutic target.