Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia.
Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia.
复制标题
肺炎支原体肺炎患儿支气管肺泡灌洗液中可溶性B7-H3和白细胞介素36浓度升高
DOI：
10.1186/s12879-016-1555-6
复制
发表时间：
2016-05-17
影响因子：
3.7
通讯作者：
Yan Y
中科院分区：
文献类型：
--
作者：
Chen Z;Zhao X;Zhang X;Zhang G;Sun H;Jiang W;Wang Y;Zhu C;Ji W;Yan Y
本研究旨在探讨支气管肺泡灌洗液（BALF）中白细胞介素36（IL-36）和可溶性B7-H3（sB 7-H3）水平与临床及实验室检查的关系。35例M.肺炎（MPP）和15名对照受试者入组。采用酶联免疫吸附法检测支气管肺泡灌洗液（BALF）中sB 7-H3和IL-36的浓度，了解MPP患儿的临床特征。MPP患儿血清sB 7-H3和IL-36水平均显著高于对照组（P均< 0.05）。同时，有胸腔积液的患儿血清sB 7-H3和IL-36水平显著高于无胸腔积液的患儿（均P < 0.05）。BALF中sB 7-H3浓度与IL-36浓度呈显著正相关（r = 0.796，P < 0.0001），sB 7-H3浓度与发热时间（r = 0.427，P = 0.11）和住院时间（r = 0.345，P = 0.043）相关。治疗后恢复期血清sB 7-H3和IL-36水平均显著降低（P均< 0.05）。可溶性B7-H3和IL-36在M. pneumoniae感染和sB 7-H3可作为MPP的预后预测因子或生物标志物。本文的在线版本（doi：10.1186/s12879-016-1555-6）包含补充材料，可供授权用户使用。
The purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings. A total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained. Children with MPP had significantly higher levels of sB7-H3 and IL-36 compared to control subjects (both P < 0.05). Meanwhile, children with pleural effusion had significantly higher levels of sB7-H3 and IL-36 compared to children without pleural effusion (both P < 0.05). BALF concentration of sB7-H3 was strongly associated with concentration of IL-36 (r = 0.796, P < 0.0001) and sB7-H3 was correlated with duration of fever (r = 0.427, P = 0.11) and length of stay (r = 0.345, P = 0.043). Both concentrations of sB7-H3 and IL-36 were significantly decreased in convalescent phase after treatment (both P < 0.05). Both soluble B7-H3 and IL-36 may play an important role in pathogenesis of M. pneumoniae infection and sB7-H3 could be useful as a prognostic predictor or biomarker of MPP. The online version of this article (doi:10.1186/s12879-016-1555-6) contains supplementary material, which is available to authorized users.