A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.
A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.
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DOI：
10.1371/journal.pone.0170946
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Turner S
中科院分区：
文献类型：
--
作者：
Abraham M;Alramadhan S;Iniguez C;Duijts L;Jaddoe VW;Den Dekker HT;Crozier S;Godfrey KM;Hindmarsh P;Vik T;Jacobsen GW;Hanke W;Sobala W;Devereux G;Turner S
母亲在怀孕期间吸烟与出生体重下降有关，但这种关系开始时的怀孕并不确定。我们提出了一个系统的文献综述，描述了母亲在怀孕期间吸烟和胎儿大小的超声测量之间的关联，以及伴随的荟萃分析。研究选自电子数据库（奥维德、EMBASE和Google Scholar），这些数据库检查了母亲吸烟或烟雾暴露与产前胎儿超声测量之间的关联。结果测量是第一，第二或第三孕期胎儿测量。共识别出284篇摘要，16篇论文被纳入综述，荟萃分析包括来自8个人群的数据。母亲吸烟与孕中期头部尺寸减小有关（平均减少0.09标准差（SD）[95% CI 0.01，0.16]）和股骨长度（0.06 [0.01，0.10]）和妊娠晚期头部尺寸减小（0.18 SD [0.13，0.23]）、股骨长度（0.27 SD [0.21，0.32]）和估计胎儿体重（0.18 SD [0.11，0.24]）。与较低的吸烟量相比，母亲吸烟量较高与第二个（平均差异0.09 SD [0，0.19]）和第三个（0.15 SD [0.03，0.26]）妊娠期头部大小的z评分较低相关。与从不吸烟的母亲相比，那些在怀孕前后戒烟的母亲的胎儿测量值并没有减少。母亲在怀孕期间吸烟与前三个月后胎儿测量结果减少有关，特别是头部大小和股骨长度减少。如果母亲在怀孕期间戒烟或减少吸烟量，这些影响可能会减弱。
Maternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between maternal smoking during pregnancy and ultrasound measurements of fetal size, together with an accompanying meta-analysis. Studies were selected from electronic databases (OVID, EMBASE and Google Scholar) that examined associations between maternal smoking or smoke exposure and antenatal fetal ultrasound measurements. Outcome measures were first, second or third trimester fetal measurements. There were 284 abstracts identified, 16 papers were included in the review and the meta-analysis included data from eight populations. Maternal smoking was associated with reduced second trimester head size (mean reduction 0.09 standard deviation (SD) [95% CI 0.01, 0.16]) and femur length (0.06 [0.01, 0.10]) and reduced third trimester head size (0.18 SD [0.13, 0.23]), femur length (0.27 SD [0.21, 0.32]) and estimated fetal weight (0.18 SD [0.11, 0.24]). Higher maternal cigarette consumption was associated with a lower z score for head size in the second (mean difference 0.09 SD [0, 0.19]) and third (0.15 SD [0.03, 0.26]) trimesters compared to lower consumption. Fetal measurements were not reduced for those whose mothers quit before or after becoming pregnant compared to mothers who had never smoked. Maternal smoking during pregnancy is associated with reduced fetal measurements after the first trimester, particularly reduced head size and femur length. These effects may be attenuated if mothers quit or reduce cigarette consumption during pregnancy.