MIGRATION OF MAST-CELLS IN THE DEVELOPING RAT-BRAIN
MIGRATION OF MAST-CELLS IN THE DEVELOPING RAT-BRAIN
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DOI：
10.1016/0165-3806(90)90077-c
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发表时间：
1990-11-01
期刊：
影响因子：
--
通讯作者：
THEOHARIDES, TC
中科院分区：
文献类型：
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作者：
LAMBRACHTHALL, M;DIMITRIADOU, V;THEOHARIDES, TC
众所周知，肥大细胞来源于骨髓，以未成熟细胞的形式进入组织，在局部微环境因素下分化。然而，目前尚不清楚这些细胞是如何以及何时进入大脑的；此外，肥大细胞在发育中的大鼠大脑中的定位与成年动物的不同。我们的解剖和形态观察表明，在胚胎晚期和出生后11天，大鼠脑内肥大细胞仅集中在间脑周围的软脑膜、脉络膜裂和脉络丛内。组织化学显示，这些细胞仅含有少量甲苯胺蓝异染颗粒，提示为“粘膜”型，不含肝素。随后，在出生后11天至13天的过渡期，这些细胞沿着海马伞血管、海马体血管和丘脑穿透血管向丘脑背外侧核和后外侧核迁移。这些细胞含有更多的异染颗粒，从第13天开始，它们在丘脑的血管周围定位，有大量的异染颗粒，类似于成熟的丘脑和浆膜肥大细胞。
Mast cells are known to derive from the bone marrow and enter the tissues as immature cells which differentiate under local microenvironmental factors. However, it has not been known how and when these cells enter the brain; moreover, the localization of mast cells in the developing rat brain differs from that of the adult animals. Our anatomical and morphological observations showed that during late embryonic stages and the first 11 days after birth, rat brain mast cells were exclusively concentrated with the pia mater surrounding the diencephalon, the choroid fissure and within the choroid plexus. Histochemically, these cells contained only a few toluidine blue metachromatic, granules, suggesting a ''mucosal'' phenotype and the absence of heparin. Later, during a transitional phase from postnatal from postnatal day 11 to 13, these cells migrated along blood vessels of the fimbria, the hippocampus and the penetrating vessels of the thalamus into the dorsolateral and posterolateral thalamic nuclei. These cells contained more metachromatic granules, and from day 13 on, they assumed their adult perivascular localization within the thalamus with numerous metachromatic granules similar to those described for mature thalamic and serosal mast cells.