Factor in arachis oil depressing sensitivity to tuberculin in B.C.G.-infected guineapigs.
Factor in arachis oil depressing sensitivity to tuberculin in B.C.G.-infected guineapigs.
复制标题
花生油中抑制 B.C.G. 感染豚鼠对结核菌素敏感性的因素。
DOI：
10.1016/s0140-6736(56)90529-3
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发表时间：
1956
期刊：
影响因子：
168.9
通讯作者：
A. J. Martin
中科院分区：
文献类型：
--
作者：
D. A. Long;A. J. Martin
单次皮下注射花生油会轻微但显著地降低敏感性。纯化产生无毒级分，其在0.000006 mg.每公斤的体重，降低敏感性的程度与5 mg/kg醋酸可的松的剂量相当。kg.，这是最有效的。活性物质似乎是具有约10-14个碳原子的胺。一个丰富的来源是植物卵磷脂，来自花生或大豆。蛋黄中含有一种类似的物质，如果不是完全相同的话。这一因素对科本内特等人的工作的影响。（1954）关于蛋黄的抗风湿特性的研究。
Single s/c injections of arachis oil depressed sensitivity slightly but significantly. Purification yielded a non-toxic fraction which, in a dose of 0.000006 mg. per kg. of body wt, depressed sensitivity to a degree comparable with that obtained with cortisone acetate in a dose of 5 mg./kg., which is maximally effective. The active substance appears to be an amine with about 10-14 carbon atoms. A rich source is vegetable lecithin, derived from groundnuts or soya beans. A similar, if not identical, substance is contained in egg-yolk. The bearing of this factor on the work of Coburnet al.(1954) on the anti-rheumatic properties of egg-yolk is discussed.