High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.
High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.
复制标题
使用7 T MRI对排尿功能障碍的多发性硬化症女性进行膀胱相关网络中排尿和静息状态之间的脑连接的高度空间相关性研究。
DOI：
10.1007/s00345-021-03599-4
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发表时间：
2021-09
影响因子：
3.4
通讯作者：
Khavari R
中科院分区：
文献类型：
--
作者：
Shi Z;Tran K;Karmonik C;Boone T;Khavari R
一些研究使用功能磁共振成像（fMRI）和并发尿动力学（UDS）测试报道了排尿过程中的脑激活和功能连接（FC）。然而，由于UDS手术的侵入性，非侵入性静息状态fMRI正在被探索作为一种潜在的替代方法。本研究的目的是评估利用静息状态作为一种非侵入性替代方法来研究大脑中膀胱相关网络的可行性。我们定量比较了以下状态下属于膀胱相关网络的大脑区域的FC：使用在7 T和3 T时获得的功能磁共振成像数据，对9名患有排尿功能障碍的多发性硬化症女性进行了休息时的“强烈排尿欲望”、“排尿开始（或尝试排尿）”和“排尿（或持续尝试排尿）”。受试者间相关性分析表明，所有受试者的排尿（或持续尝试排尿）都是通过相似的网络连接实现的。基于任务的膀胱相关网络仅在排尿（或持续尝试排尿）过程中与静息状态的内在网络相似，而在其他状态下则不同。静息状态功能磁共振成像可以潜在地用于准确反映排尿（或持续尝试排尿）网络。对于研究强烈的排尿欲望和排尿开始（或试图排尿开始）的影响，仍然需要同时进行UDS测试。在线版本包含补充材料，可在10.1007/s00345-021-03599-4获得。
Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potential alternative. The purpose of this study is to evaluate the feasibility of utilizing resting states as a non-invasive alternative for investigating the bladder-related networks in the brain. We quantitatively compared FC in brain regions belonging to the bladder-related network during the following states: ‘strong desire to void’, ‘voiding initiation (or attempt at voiding initiation)’, and ‘voiding (or continued attempt of voiding)’ with FC during rest in nine multiple sclerosis women with voiding dysfunction using fMRI data acquired at 7 T and 3 T. The inter-subject correlation analysis showed that voiding (or continued attempt of voiding) is achieved through similar network connections in all subjects. The task-based bladder-related network closely resembles the resting-state intrinsic network only during voiding (or continued attempt of voiding) process but not at other states. Resting states fMRI can be potentially utilized to accurately reflect the voiding (or continued attempt of voiding) network. Concurrent UDS testing is still necessary for studying the effects of strong desire to void and initiation of voiding (or attempt at initiation of voiding). The online version contains supplementary material available at 10.1007/s00345-021-03599-4.
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