Lipid mediators regulating pain sensitivity
Lipid mediators regulating pain sensitivity
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DOI：
10.1016/j.prostaglandins.2004.09.008
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发表时间：
2005-09-01
影响因子：
2.9
通讯作者：
Porreca, F
中科院分区：
文献类型：
--
作者：
Malan, TP;Porreca, F
本次研讨会的论文表明，脂质分子是普遍存在的信使，参与细胞内信号传递，在细胞间通讯中起作用，并作为神经递质。本文综述了脂质信使在调节特定生理功能中的作用，即神经系统中有害感觉信息（疼痛）的传递。脂质分子在疼痛敏感性的调节中起主要作用。六种类型的脂质分子（前列腺素、磷脂酰肌醇二磷酸、神经酰胺、花生四烯酸脂氧合酶代谢物、脂肪酰基多巴胺和酰基乙醇酰胺）已被证明对疼痛反应的调节系统具有重要作用。这些分子通过与不同的受体系统相互作用来发挥作用。它们参与疼痛反应调节的证据来自于它们与已知在疼痛敏感性调节中重要的信号系统的相互作用的体外证明，在某些情况下，来自于它们在体内给药后调节疼痛敏感性的能力的证明。其中一类脂质介质，酰基乙醇酰胺，抑制疼痛反应，而其他的似乎增强疼痛敏感性。鉴于我们对脂质组学的理解的快速增长，在本期的论文中很明显，几乎可以肯定的是，额外的脂质介质将被确定为疼痛反应调节的核心。(c) 2004 Elsevier Inc.版权所有。
The papers in this symposium demonstrate that lipid molecules are ubiquitous messengers that participate in intracellular signaling, function in intercellular communication, and serve as neurotransmitters. This review examines the contribution of lipid messengers in regulating a specific physiological function, the transmission of noxious sensory information (pain) in the nervous system. Lipid molecules play major roles in the modulation of pain sensitivity. Six types of lipid molecules (prostanoids, phosphatidyl inositol bisphosphate, ceramide, lipoxygenase metabolites of arachidonic acid, fatty acyl dopamines, and acylethanolamides) have been shown to modulate systems important in the regulation of pain responses. These molecules exert their actions by interacting with varied receptor systems. Evidence for their participation in the regulation of pain responses comes from in vitro demonstrations of their interactions with signaling systems known to be important in the regulation of pain sensitivity and, in some cases, from demonstration of their ability to modulate pain sensitivity after in vivo administration. One of these classes of lipid mediators, the acylethanolamides, inhibits pain responses, while the others appear to enhance pain sensitivity. Given the rapid growth in our understanding of lipidomics, evident in the papers of this issue, it is virtually certain that additional lipid mediators will be identified as being central to the regulation of pain responses. (c) 2004 Elsevier Inc. All rights reserved.