Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer
Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer
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DOI：
10.1164/rccm.200708-1142oc
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发表时间：
2008-02-01
影响因子：
24.7
通讯作者：
Franklin, Wilbur A.
中科院分区：
文献类型：
--
作者：
Jonsson, Steinn;Varella-Garcia, Marileila;Franklin, Wilbur A.
理由：肺癌（LC）的发展伴随着气道粘膜的电场变化，这可能具有预后重要性。目的：通过荧光原位杂交（FISH）技术，比较流行LC患者与对照组在组织学异常增生评分和染色体动脉瘤方面的差异。方法：采用包含6号染色体着丝粒、5p15.2、7p12（表皮生长因子受体）和8q24 v-myc髓细胞瘤病病毒癌基因同源（MYC）序列的四色FISH探针，对44例LC患者和90例无癌对照组的最晚期支气管组织学病变进行评估。组织学分级分为发育不良（中度或重度）或原位癌（CIS）。测量和主要结果：32例患者CIS为最高组织学分级，102例患者发育不良为最高组织学分级（中度54例，重度48例）。LC病例中有64%出现染色体切除，而对照组只有31%出现染色体切除（优势比[OR]， 4.68； 95%可信区间[CI]）。1.97 - -11.04)。在任何程度的不典型增生中，FISH和LC阳性的OR为2.28 （95% Cl, 0.75-6.86）。在CIS患者中，FISH和LC阳性OR为5.84 （95% Cl, 1.31-26.01）。结论：染色体切除与LC相关。前瞻性检查动脉瘤作为预测LC的前驱病变是必要的。
Rationale: The development of lung cancer (LC) is accompanied by field changes in the airway mucosa that may have prognostic importance.Objectives: To compare patients with prevalent LC to control subjects regarding their histologic dysplasia scores and chromosomal aneusomy as measured by fluorescence in situ hybridization (FISH).Methods: The most advanced bronchial histology lesion was assessed from each of 44 LC cases and 90 cancer-free control subjects using a four-color FISH probe set encompassing the chromosome 6 centromere, 5p15.2, 7p12 (epidermal growth factor receptor), and 8q24 v-myc myelocytomatosis viral oncogene homolog (MYC) sequences. Histology grades were coded as dysplasia (moderate or severe) or carcinoma in situ (CIS).Measurements and Main Results: CIS was the highest histologic grade for 32 subjects, and dysplasia was the highest grade for 102 subjects (54 moderate, 48 severe). Chromosomal aneusomy was seen in 64% of the LC cases, but in only 31% of the control subjects (odds ratio [OR], 4.68; 95% confidence interval [CI]. 1.97-11.04). Among those with any level of dysplasia, the OR for positive FISH and LC was 2.28 (95% Cl, 0.75-6.86). Among those with CIS, the OR for positive FISH and LC was 5.84 (95% Cl, 1.31-26.01).Conclusions: Chromosomal aneusomy is associated with LC. Prospective examination of aneusomy as a precursor lesion that predicts LC is needed.