Stream-Related Preferences of Inputs to the Superior Colliculus from Areas of Dorsal and Ventral Streams of Mouse Visual Cortex
Stream-Related Preferences of Inputs to the Superior Colliculus from Areas of Dorsal and Ventral Streams of Mouse Visual Cortex
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DOI：
10.1523/jneurosci.3067-12.2013
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发表时间：
2013-01-23
影响因子：
5.3
通讯作者：
Burkhalter, Andreas
中科院分区：
文献类型：
--
作者：
Wang, Quanxin;Burkhalter, Andreas
先前对小鼠视觉皮层内连接的研究揭示了两个类似于灵长类动物背侧流和腹侧流的子网络。虽然钙成像研究表明，许多地区的腹侧流有很高的空间敏锐度，而地区的背侧流是高度敏感的瞬态视觉刺激，有一些功能的不一致性，挑战一个简单的分组到“什么/感知”和“在哪里/行动”流已知的灵长类动物。上级丘（SC）是多模态感觉信息处理和定向眼睛，头部和身体的运动控制的主要中心。视觉处理是在浅层，而运动前活动产生于深层的SC。因为SC是已知的接收来自视觉皮层的输入，我们问是否从10个视觉领域的背侧和腹侧流的预测终止在差分深度配置文件内的SC。我们发现，从初级视觉皮层的输入是迄今为止最强的。从腹侧流的投影基本上较弱，而spararterial输入起源于背侧流的地区。重要的是，我们发现，腹侧流输入终止于浅层，而背侧流输入往往是不规则的，要么同样投射到浅层和深层，要么强烈倾向于深层。结果表明，解剖学定义的腹侧和背侧流包含属于不同的功能系统，专门用于处理视觉信息和视觉引导的行动，分别领域。
Previous studies of intracortical connections in mouse visual cortex have revealed two subnetworks that resemble the dorsal and ventral streams in primates. Although calcium imaging studies have shown that many areas of the ventral stream have high spatial acuity whereas areas of the dorsal stream are highly sensitive for transient visual stimuli, there are some functional inconsistencies that challenge a simple grouping into "what/perception" and "where/action" streams known in primates. The superior colliculus (SC) is a major center for processing of multimodal sensory information and the motor control of orienting the eyes, head, and body. Visual processing is performed in superficial layers, whereas premotor activity is generated in deep layers of the SC. Because the SC is known to receive input from visual cortex, we asked whether the projections from 10 visual areas of the dorsal and ventral streams terminate in differential depth profiles within the SC. We found that inputs from primary visual cortex are by far the strongest. Projections from the ventral stream were substantially weaker, whereas the sparsest input originated from areas of the dorsal stream. Importantly, we found that ventral stream inputs terminated in superficial layers, whereas dorsal stream inputs tended to be patchy and either projected equally to superficial and deep layers or strongly preferred deep layers. The results suggest that the anatomically defined ventral and dorsal streams contain areas that belong to distinct functional systems, specialized for the processing of visual information and visually guided action, respectively.